Tissue Eng Regen Med.
2018 Apr;15(2):231-247. 10.1007/s13770-017-0106-6.
Osteogenic Nanofibrous Coated Titanium Implant Results in Enhanced Osseointegration: In Vivo Preliminary Study in a Rabbit Model
- Affiliations
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- 1Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India.
- 2Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai 400076, India. jb@iitb.ac.in
- 3Tata Memorial Centre, HBNI, Mumbai 400012, India.
- 4Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai 410210, India.
- 5Wadhwani Research Centre for Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India.
- KMID: 2410517
- DOI: http://doi.org/10.1007/s13770-017-0106-6
Abstract
- A titanium implant surface when coated with biodegradable, highly porous, osteogenic nanofibrous coating has shown enhanced intrinsic osteoinductive and osteoconductive properties. This coating mimics extracellular matrix resulting in differentiation of stem cells present in the peri-implant niche to osteoblast and hence results in enhanced osseointegration of the implant. The osteogenic nanofibrous coating (ONFC) consists of poly-caprolactone, gelatin, nano-sized hydroxyapatite, dexamethasone, ascorbic acid and beta-glycerophosphate. ONFC exhibits optimum mechanical properties to support mesenchymal stem cells and steer their osteogenic differentiation. ONFC was subjected to various characterization tests like scanning electron microscopy, Fourier-transform infrared spectroscopy, x-ray diffractometry, thermal degradation, biomineralization, mechanical properties, wettability and proliferation assay. In pre-clinical animal trials, the coated implant showed enhanced new bone formation when placed in the tibia of rabbit. This novel approach toward implant bone integration holds significant promise for its easy and economical coating thus marking the beginning of new era of electrospun osteogenic nanofibrous coated bone implants.
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