Korean J Clin Oncol.  2017 Dec;13(2):92-95. 10.14216/kjco.17013.

Clinicopathologic characteristics of teenage sporadic colorectal cancer

• Lee JJ
• Kim SH
• Lim SB
• Lee JL
• Kim CW
• Yoon YS
• Park IJ
• Yu CS
• Kim JC

• KMID: 2405647
• DOI: http://doi.org/10.14216/kjco.17013

Abstract

PURPOSE
Colorectal cancer (CRC) is generally considered a disease of old age. Most CRCs are diagnosed at age 50 and over. CRC rarely occurs in teenagers, and the clinical features and prognosis of CRC are not clear in this population. The aim of this study was to uncover the clinicopathologic characteristics of teenage sporadic CRC.
METHODS
Of the 21,042 patients who underwent operation for primary CRC at Asan Medical Center between July 1989 and December 2014, 19 cases (0.09%) without a familial history of CRC before 20 years of age at diagnosis were enrolled in this study. The clinicopathologic features of the teenage sporadic CRC patients were retrospectively reviewed.
RESULTS
Of the 19 patients, 16 patients (84.2%) were male. The most common primary site was the left colon (descending colon & sigmoid colon) in nine patients. With respect to histologic type, adenocarcinoma represented 57.8% of cases, mucinous adenocarcinoma, 31.5%, and signet ring cell carcinoma, 10.5%. Six (31.5%) patients showed peritoneal seeding at presentation. In survival analysis, the 5-year overall survival rate of the patients who underwent curative surgery was 71.3%.
CONCLUSION
Teenage sporadic CRC is a very rare disease and the proportion of patients with a poor histologic subtype is high, but early detection and radical treatment can lead to favorable survival rates.

Keyword

Colorectal cancer; Teenage; Sporadic Cancer

MeSH Terms

Adenocarcinoma
Adenocarcinoma, Mucinous
Adolescent
Carcinoma, Signet Ring Cell
Chungcheongnam-do
Colon
Colon, Sigmoid
Colorectal Neoplasms*
Diagnosis
Humans
Male
Prognosis
Rare Diseases
Retrospective Studies
Survival Rate