J Obes Metab Syndr.  2017 Dec;26(4):287-290. 10.7570/jomes.2017.26.4.287.

Circulating Monocyte Chemoattractant Protein-1 Levels and Lumbar Bone Mineral Density in Korean Women

• Lee SK

• KMID: 2404811
• DOI: http://doi.org/10.7570/jomes.2017.26.4.287

Abstract

BACKGROUND
Monocyte chemoattractant protein-1 (MCP-1) is expressed in adipose tissue, macrophages, endothelial cells, and osteoblasts by parathyroid hormone administration. Circulating MCP-1 levels are positively correlated with the degree of obesity. However, whether circulating MCP-1 affects bone metabolism is unclear. Therefore, in this study, the association between circulating MCP-1 levels and lumbar bone mineral density (BMD) based on menopausal status was assessed.
METHODS
We recruited 109 premenopausal and 46 postmenopausal Korean women and examined the association between circulating MCP-1 concentrations and various parameters including lumbar BMD based on menopausal status.
RESULTS
A significant increase in body weight, abdominal circumference, body mass index, and MCP-1 levels (from 245.9±73.5 to 336.5±101.7 pg/mL) and significant decrease (from 0.992±0.114 to 0.772±0.113 g/cm²) in lumbar BMD were observed after menopause. However, circulating MCP-1 levels were not correlated with any parameters including lumbar BMD in premenopausal or postmenopausal women.
CONCLUSION
Circulating MCP-1 levels were not correlated with lumbar BMD regardless of menopausal status.

Keyword

Monocyte chemoattractant protein-1; Bone density; Women

MeSH Terms

Adipose Tissue
Body Mass Index
Body Weight
Bone Density*
Chemokine CCL2*
Endothelial Cells
Female
Humans
Macrophages
Menopause
Metabolism
Monocytes*
Obesity
Osteoblasts
Parathyroid Hormone
Chemokine CCL2
Parathyroid Hormone