Clin Hypertens.
2017 ;23(1):13. 10.1186/s40885-017-0068-y.
Pathophysiology of copeptin in kidney disease and hypertension
- Affiliations
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- 1Department of Internal Medicine, Nephrology Division, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey.
- 2Suleyman Demirel University, Çünür, Doğu yerleşkesi, Isparta Merkez/Isparta, Postal Code: 32260 Isparta, Turkey. afsarbrs@yahoo.com
- KMID: 2404098
- DOI: http://doi.org/10.1186/s40885-017-0068-y
Abstract
- Copeptin is derived from the cleavage of the precursor of arginine vasopressin (AVP), produced in an equimolar ratio in hypothalamus and processed during axonal transport AVP is an unstable peptide and has a short half-life of 5-20 min. Unlike AVP, copeptin is a stable molecule and can easily be measured. Recent evidence suggest that increased copeptin levels have been associated with worse outcomes in various clinical conditions including chronic kidney disease (CKD) and hypertension. In this review, the data regarding copeptin with kidney function (evaluated as glomerular filtration rate, increased albumin/protein excretion or both) and hypertension with regard to performed studies, prognosis and pathogenesis was summarised.
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