J Korean Child Neurol Soc.
2017 Dec;25(4):215-220. 10.26815/jkcns.2017.25.4.215.
Prognosis in Late-Onset Febrile Seizure
- Affiliations
-
- 1Department of Pediatrics, Korea University Guro Medical Center, Seoul, Korea. gunhaaa@korea.ac.kr, merr2020@gmail.com
- 2Biostatistical Consulting lab, Medical Science Research Center, Korea University College of Medicine, Seoul, Korea.
- 3Department of Pediatrics, Korea University Anam Medical Center, Seoul, Korea.
- 4Department of Pediatrics, Korea University Ansan Medical Center, Gyeonggi-do, Korea.
- KMID: 2403723
- DOI: http://doi.org/10.26815/jkcns.2017.25.4.215
Abstract
- PURPOSE
There is a paucity of evidence about prognosis after a first febrile seizure in older children. We investigated the prognosis and potential risk factors associated with subsequent unprovoked seizures in children who had experienced a first febrile seizure over 6 years of age, which we termed as late-onset febrile seizure.
METHODS
We included all patients six years or older who presented to the emergency department with a febrile seizure between 2009 and 2015. Clinical data was collected by chart review and parents were contacted for information on seizure progress. We used the Cox proportional-hazards model and Kaplan-Meier analysis for evaluating the risk factors for subsequent unprovoked seizures.
RESULTS
Of 247 patients, we excluded 168 children who had a history of epilepsy, unprovoked, or febrile seizure and who were followed-up for period less than six months. Overall, 79 patients were classified as having had a first late-onset febrile seizure. During follow-up of 34.9±25.7(mean±SD) months, unprovoked seizure recurred in 7 of 79 patients (9%). The cumulative probability of seizure recurrence was 4% at 6 months, 6% at 1 year and 9% at 2 years. Clinical variables predictive of subsequent unprovoked seizures were not proved.
CONCLUSION
This is the first multicenter study focusing on prognosis after a late-onset febrile seizure in children six years or older. The percentage of subsequent unprovoked seizure in patients with late-onset febrile seizure was 9% at 2 years of follow-up. Prospective follow-up study with longer duration is warranted.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Selection of High Risk Group According to Risk Factors of Recurrent Febrile Seizures
- A Study on the Clinical Features and the Predictors of Febrile Seizure Plus
- Risk Factors for Recurrence of Febrile Seizure in Children
- Epilepsy in children with a history of febrile seizures
- Comparative Study of Febrile or Benign Seizures Associated with Acute Gastroenteritis
