Res Vestib Sci.  2017 Dec;16(4):156-160. 10.21790/rvs.2017.16.4.156.

Brain Hypometabolism in Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome

  • 1Department of Neurology, Chonbuk National University Medical School, Jeonju, Korea.
  • 2Department of Neurology, Ulsan University Hospital, Ulsan, Korea.
  • 3Department of Nuclear Medicine, Chonbuk National University Medical School, Jeonju, Korea.


Cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) is a slowing progressive ataxic disorder characterized by bilateral vestibulopathy, cerebellar ataxia and somatosensory impairment. Autonomic dysfunction is recently considered as a core feature in CANVAS in addition to these symptoms. In most cases, patients with CANVAS show cerebellar atrophy in brain imaging, but some cases show minimal or no atrophy of cerebellum. Brain (18F)-fluoro-2-deoxy-D-glucose positron emission tomography (¹â¸F-FDG PET) study can be a complimentary tool to diagnosis CANVAS in cases of no structural abnormality such as cerebellar atrophy. Hereby, we present a case of CANVAS with minimal atrophy of cerebellum but showing a prominent hypometabolism in cerebellum, thalamus and posterior cingulate cortex in ¹â¸F-FDG PET.


Bilateral vestibulopathy; Cerebellar ataxia; Primary dysautonomias; Positron-emission tomography
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