J Clin Neurol.  2018 Jan;14(1):16-21. 10.3988/jcn.2018.14.1.16.

Subjective Cognitive Complaints and Objective Cognitive Impairment in Parkinson's Disease

• Hong JY
• Lee Y
• Sunwoo MK
• Sohn YH
• Lee PH

• KMID: 2399594
• DOI: http://doi.org/10.3988/jcn.2018.14.1.16

Abstract

BACKGROUND AND PURPOSE
Subjective cognitive complaints (SCCs) are very common in patients with Parkinson's disease (PD). However, the relationship between SCCs and objective cognitive impairment is still unclear. This study aimed to determine whether SCCs are correlated with objective cognitive performance in patients with PD.
METHODS
Totals of 148 cognitively normal patients, 71 patients with mild cognitive impairment (MCI), and 31 demented patients were recruited consecutively from a movement-disorders clinic. Their SCCs and cognitive performances were evaluated using the Cognitive Complaints Interview (CCI) and a comprehensive neuropsychological battery.
RESULTS
The CCI score increased with age, duration of PD, and depression score, and was inversely correlated with cognitive performance. The association between CCI score and performance remained significant after adjustment for the depression score, age, and duration of PD. The CCI score could be used to discriminate patients with dementia from cognitively normal and MCI patients [area under the receiver operating characteristics curve (AUC) of 0.80], but not patients with MCI or dementia from cognitively normal patients (AUC of 0.67).
CONCLUSIONS
SCCs as measured by the CCI are strongly correlated with objective cognitive performance in patients with PD. The CCI can also be used to screen for dementia in patients with PD.

Keyword

Parkinson's disease; cognition; cognitive dysfunction; dementia

MeSH Terms

Cognition
Cognition Disorders*
Dementia
Depression
Humans
Mild Cognitive Impairment
Parkinson Disease*
ROC Curve

Figure

• 

  Fig. 1 Proportions of CCI scores in the three cognitive groups. CCI: Cognitive Complaints Interview, CN: cognitively normal, D: dementia, MCI: mild cognitive impairment.

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  Fig. 2 ROC curves for discriminating (A) group MCI or D from group CN, and (B) group D from group CN or MCI, AUC, area under the ROC curve. CN: cognitively normal, D: dementia, MCI: mild cognitive impairment, ROC: receiver operating characteristics.

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