J Korean Med Sci.
2018 Jan;33(1):e6. 10.3346/jkms.2018.33.e6.
Plasma MicroRNA-21, 26a, and 29a-3p as Predictive Markers for Treatment Response Following Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma
- Affiliations
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- 1Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea. jaeyoun620@gmail.com
- 2Human Genome Research & Bio-resource Center, Ajou University Medical Center, Suwon, Korea.
- 3Office of Biostatistics, Ajou University School of Medicine, Suwon, Korea.
- 4Center of Biomedical Data Science, Yonsei University Wonju College of Medicine, Wonju, Korea.
- 5Department of Radiology, Ajou University School of Medicine, Suwon, Korea.
- KMID: 2399163
- DOI: http://doi.org/10.3346/jkms.2018.33.e6
Abstract
- BACKGROUND
We investigated an association between the levels of plasma microRNA (miRNA)-21, -26a, and -29a-3p and treatment outcomes following transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC).
METHODS
A total of 198 patients with TACE-treated HCC were followed up for TACE refractoriness and liver transplantation (LT)-free survival. Pretreatment plasma miRNA-21, -26a, and -29a-3p levels were measured using quantitative real-time polymerase chain reaction.
RESULTS
During the mean follow-up of 22.3 (range, 0.7-79) months, 118 (59.6%) patients exhibited TACE refractoriness. Multivariate analyses showed that expression of a specific combination of miRNAs (miRNA-21 ≥ 2.5, miRNA-26a ≥ 1.5, and miRNA-29a-3p < 0.4) was associated with early TACE refractoriness (within 1 year; hazard ratio [HR], 2.32; 95% confidence interval [CI], 1.08-4.99; P = 0.031) together with tumor size (HR, 4.62; 95% CI, 1.50-14.21; P = 0.008), and macrovascular invasion (HR, 3.80; 95% CI, 1.19-12.20; P = 0.025). However, miRNA-21, -26a, and -29a-3p levels were not significantly associated with overall TACE refractoriness or LT-free survival. Additionally, large tumor size and macrovascular invasion were common predictive factor of overall TACE refractoriness and survival.
CONCLUSION
Combination of plasma miRNA-21, -26a, and -29a-3p expression could predict early TACE refractoriness in patients with TACE-treated HCC.
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