Korean J Biol Psychiatry.
2017 Nov;24(4):188-195. 10.0000/kjbp.2017.24.4.188.
Association of Therapeutic Response and Change of Mismatch Negativity in Schizophrenia Patients
- Affiliations
-
- 1Department of Psychiatry, Kyung Hee University Hospital, Seoul, Korea. menuhinwskang@khu.ac.kr
- 2Department of Biomedical Science, Graduate School, Eulji University, Daejeon, Korea.
- 3Department of Psychiatry, College of Medicine, Kyung Hee University, Seoul, Korea.
- KMID: 2398924
- DOI: http://doi.org/10.0000/kjbp.2017.24.4.188
Abstract
OBJECTIVES
Schizophrenia is characterized by disturbances in perception and cognition. Attenuated mismatch negativity (MMN) reflects central auditory dysfunction in schizophrenia. The aim of this study is to compare MMN changes before and after treatment in schizophrenia patients and to assess their association with treatment response.
METHODS
Twenty-three schizophrenia patients underwent an oddball paradigm. MMN was calculated by the difference waveforms of the event-related potentials (ERPs) elicited by subtracting standard from deviant stimulus. The clinical symptoms were measured by the Positive and Negative Syndrome Scale (PANSS), the Psychotic Symptom Rating Scale (PSYRATS). Follow-up evaluation was conducted when the PANSS total score decreased by 30% or more (treatment response group) or before discharge (non-response group).
RESULTS
The treatment response group showed significantly larger MMN amplitude improvement and latency reduction than the non-response group after treatment (Fz ; mean amplitude p = 0.035, FCz ; p = 0.041). The auditory hallucination group showed shorter latency than that of the group without hallucinations. Additionally, auditory hallucination was associated with prolonged MMN latency and shortened after treatment in the auditory hallucination response group (Fz ; p = 0.048).
CONCLUSIONS
These results suggest that the attenuated MMN amplitude reflects the progression of the disease. The increment of MMN amplitude and shortening of latency after treatment may reflect cognitive functional recovery of central auditory sensory processing.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Mismatch Negativity Indices as a Prognostic Factor for Remission in Schizophrenia
- Association between Mismatch Negativity and Functional Status in Patients with Schizophrenia
- Effect of Ketamine on the Echoic Memory Process: The Mismatch Negativity and Glutamate Receptor System in Schizophrenia
- Electroencephalography and Schizophrenia
- Predicting Prognosis in Patients with First Episode Psychosis Using Mismatch Negativity : A 1 Year Follow-up Study
