Pediatr Gastroenterol Hepatol Nutr.  2017 Dec;20(4):222-226. 10.5223/pghn.2017.20.4.222.

Celiac Disease in South Jordan

• Altamimi E

• KMID: 2398903
• DOI: http://doi.org/10.5223/pghn.2017.20.4.222

Abstract

PURPOSE
Celiac disease, an autoimmune enteropathy triggered by exposure to gluten, is not uncommon in South Jordan. However, its prevalence is underestimated due to lack of physician awareness of the diversity of disease presentation. The clinical spectrum includes classic gastrointestinal manifestations, as well as rickets, iron-deficiency anemia, short stature, elevated liver enzymes, and edema. Our goal was to evaluate celiac disease presentation in clinically diagnosed children.
METHODS
Retrospective study included all children diagnosed with celiac disease between September 2009 and September 2015. Hospital charts were reviewed. Demographic data, clinical characteristics, and follow-up were recorded.
RESULTS
Thirty-five children were diagnosed with celiac disease during the study period. Mean age±standard deviation was 6.7±3.8 years (range, 2.0-14 years). There were 17 (48.6%) female patients. The average duration between onset of symptoms and diagnosis was 16.3±18.7 months. Fifteen (42.9%) patients presented with classic malabsorption symptoms, whereas 7 (20.0%) patients presented with short stature. Positive tissue transglutaminase antibodies (tTg)-immunoglobulin A (IgA) was seen in 34 (97.1%) patients. The one patient with negative tTg-IgA had IgA deficiency. Although tTG-IgA values were not available for objective documentation of compliance, clinical data (resolution of presenting abnormalities and growth improvement) assured acceptable compliance in 22 (62.9%) patients.
CONCLUSION
CD in children may present with diverse picture. Although of the small number, the non-classical presentations are not uncommon in our rural community. Gluten-free diet is the main strategy for treatment and associated with usually correction of laboratory abnormalities and improvement of growth.

Keyword

Celiac disease; Pediatrics; Gluten free diet; Malabsorption

MeSH Terms

Anemia, Iron-Deficiency
Antibodies
Celiac Disease*
Child
Compliance
Diagnosis
Diet, Gluten-Free
Edema
Female
Follow-Up Studies
Glutens
Humans
IgA Deficiency
Jordan*
Liver
Pediatrics
Prevalence
Retrospective Studies
Rickets
Rural Population
Antibodies
Glutens

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