J Bone Metab.  2017 Nov;24(4):223-228. 10.11005/jbm.2017.24.4.223.

Relationship between Serum 25-hydroxy-vitamin D Concentration and Risk of Metabolic Syndrome in Patients with Fatty Liver

• Lim HS
• Kim TH
• Lee HH
• Kim SK
• Lee B
• Park YH

• KMID: 2397555
• DOI: http://doi.org/10.11005/jbm.2017.24.4.223

Abstract

BACKGROUND
The vitamin D deficiency rate in Koreans is still high and dietary intake is insufficient. The purpose of this study was to provide basic data for the management of metabolic syndrome (MetS) by analyzing the effect of vitamin D levels on the MetS in patients with fatty liver.
METHODS
We analyzed the MetS ratio and serum 25-hydroxy-vitamin D (25[OH]D) concentration in 151 adults diagnosed with fatty liver by using obesity index and blood profiles. We collected data on demographic factors, nutrient intake, and lifestyle habits.
RESULTS
The mean 25(OH)D concentration of all subjects was 14 ng/mL and the insufficiency and deficiency rates were 40.4% and 29.8%. The proportion of MetS was 38.4% and the mean 25(OH)D level of MetS group was 12.1 ng/mL. Low-density lipoprotein cholesterol, triglyceride, and blood glucose were higher in the MetS group than in the normal group, and the waist circumference of the male was significantly higher than that of the normal group. The results showed that the lower the vitamin D concentration, the higher the risk of MetS (odds ratio, 1.47, 95% confidence interval, 0.98-2.81; P=0.043).
CONCLUSIONS
These results suggest that serum 25(OH)D levels may be a risk factor for MetS in patients with fatty liver.

Keyword

Fatty liver; Metabolic syndrome; Vitamin D deficiency

MeSH Terms

Adult
Blood Glucose
Cholesterol
Demography
Fatty Liver*
Humans
Life Style
Lipoproteins
Male
Obesity
Risk Factors
Triglycerides
Vitamin D
Vitamin D Deficiency
Waist Circumference
Blood Glucose
Cholesterol
Lipoproteins
Vitamin D

Reference

1. Lorenzo C, Williams K, Hunt KJ, et al. The national cholesterol education program - adult treatment panel III, international diabetes federation, and world health organization definitions of the metabolic syndrome as predictors of incident cardiovascular disease and diabetes. Diabetes Care. 2007; 30:8–13.

2. Dekker JM, Girman C, Rhodes T, et al. Metabolic syndrome and 10-year cardiovascular disease risk in the Hoorn Study. Circulation. 2005; 112:666–673.

3. Laaksonen DE, Lakka HM, Niskanen LK, et al. Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol. 2002; 156:1070–1077.

4. Sabaté J, Wien M. A perspective on vegetarian dietary patterns and risk of metabolic syndrome. Br J Nutr. 2015; 113:Suppl 2. S136–S143.

5. Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357:266–281.

6. Forouhi NG, Luan J, Cooper A, et al. Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes. 2008; 57:2619–2625.

7. Ford ES, Ajani UA, McGuire LC, et al. Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults. Diabetes Care. 2005; 28:1228–1230.

8. Ford ES, Zhao G, Li C, et al. Serum concentrations of vitamin D and parathyroid hormone and prevalent metabolic syndrome among adults in the United States. J Diabetes. 2009; 1:296–303.

9. Choi HS, Kim KA, Lim CY, et al. Low serum vitamin D is associated with high risk of diabetes in Korean adults. J Nutr. 2011; 141:1524–1528.

10. Snijder MB, Lips P, Seidell JC, et al. Vitamin D status and parathyroid hormone levels in relation to blood pressure: a population-based study in older men and women. J Intern Med. 2007; 261:558–565.

11. Lee SW, Lee TY, Yang SS, et al. The association of non-alcoholic fatty liver disease and metabolic syndrome in a Chinese population. Hepatobiliary Pancreat Dis Int. 2017; 16:176–180.

12. Kotronen A, Westerbacka J, Bergholm R, et al. Liver fat in the metabolic syndrome. J Clin Endocrinol Metab. 2007; 92:3490–3497.

13. Seldeen KL, Pang M, Rodríguez-Gonzalez M, et al. A mouse model of vitamin D insufficiency: is there a relationship between 25(OH) vitamin D levels and obesity? Nutr Metab (Lond). 2017; 14:26.

14. Cimini FA, Barchetta I, Carotti S, et al. Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease. World J Gastroenterol. 2017; 23:3407–3417.

15. Choi HS. Vitamin d status in Korea. Endocrinol Metab (Seoul). 2013; 28:12–16.

16. Lee S, Park HS, Kim SM, et al. Cut-off points of waist circumference for defining abdominal obesity in the Korean population. Korean J Obes. 2006; 15:1–9.

17. National Institutes of Health. Vitamin D. Fact sheet for health professionals. Bethesda, MD: U.S. Department of Health and Human Services, National Institute of Health, Office of Dietary Supplements;2014.

18. Hollis BW. Assessment of vitamin D status and definition of a normal circulating range of 25-hydroxyvitamin D. Curr Opin Endocrinol Diabetes Obes. 2008; 15:489–494.

19. Kim D, Touros A, Kim WR. Nonalcoholic fatty liver disease and metabolic syndrome. Clin Liver Dis. 2018; 22:133–140.

20. Dixon JB, Bhathal PS, O'Brien PE. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology. 2001; 121:91–100.

21. Chitturi S, Abeygunasekera S, Farrell GC, et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology. 2002; 35:373–379.

22. Yoon H, Jeong DK, Park CE, et al. The association between gender difference with metabolic syndrome, metabolic syndrome score and serum vitamin D levels in Korean adults. Int J Food Sci Nutr. 2017; 68:121–129.

23. Lim S, Kim MJ, Choi SH, et al. Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asian subjects. Am J Clin Nutr. 2013; 97:524–530.

24. Eshraghian A. Bone metabolism in non-alcoholic fatty liver disease: vitamin D status and bone mineral density. Minerva Endocrinol. 2017; 42:164–172.