Allergy Asthma Respir Dis.  2017 Nov;5(6):331-335. 10.4168/aard.2017.5.6.331.

Sensitization to component antigens in acute idiopathic urticaria in children

Affiliations
  • 1Department of Pediatrics, Hanyang University Guri Hospital, Guri, Korea. jaewonoh@hanyang.ac.kr
  • 2Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea.

Abstract

PURPOSE
The aim of this study was to evaluate hidden allergens of acute idiopathic urticaria (AIU) in childhood by using the component-resolved diagnostics (CRD).
METHODS
We applied CRD using pathogenesis-related protein family number 10 (PR-10) and nonspecific lipid transfer proteins (nsLTP).
RESULTS
Twenty-two of the 74 AIU children (29.7%) were found to be positive on CRD. Ten children were positive to nMal d 1 for apple (value range, 1.10-40.59), 6 to rConr a 1 for hazelnut (1.53-11.97), 4 to rPru p 1 for peach (1.32-11.83). 6 to rAra h 8 for peanut (1.20-8.12), 6 to nAct d 8 for kiwi (0.85-3.32), 4 to rBet v 1 for birch (2.49-54.28), and 3 to rAln g 1 for alder (2.32-5.74). Six children were positive to nPru p 3 for peach (1.45-18.77), 4 to rCor a 8 for hazelnut (2.56-9.19), 2 to nArt v 3 for mugwort (3.40-7.42), and 3 to rBet v2 to profilin of birch (2.56-17.46). Ten children with AIU were positive to multiple component proteins. For hazelnut, 5 children were positive to PR-10 (rConr a 1) and nsLTP (rConr a 1). For peach, 3 children were positive to PR-10 (rPru p 1) and nsLTP (nPru p 3).
CONCLUSION
IgE sensitization to PR-10 or nsLTP may be allergen components for AIU in childhood.

Keyword

Urticaria; Allergen; Diagnosis

MeSH Terms

Allergens
Alnus
Arachis
Artemisia
Betula
Child*
Corylus
Diagnosis
Humans
Immunoglobulin E
Profilins
Prunus persica
Urticaria*
Allergens
Immunoglobulin E
Profilins

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