Allergy Asthma Respir Dis.  2017 Nov;5(6):331-335. 10.4168/aard.2017.5.6.331.

Sensitization to component antigens in acute idiopathic urticaria in children

• Choi YJ
• Yoon JM
• Chang YS
• Oh JW

• KMID: 2396674
• DOI: http://doi.org/10.4168/aard.2017.5.6.331

Abstract

PURPOSE
The aim of this study was to evaluate hidden allergens of acute idiopathic urticaria (AIU) in childhood by using the component-resolved diagnostics (CRD).
METHODS
We applied CRD using pathogenesis-related protein family number 10 (PR-10) and nonspecific lipid transfer proteins (nsLTP).
RESULTS
Twenty-two of the 74 AIU children (29.7%) were found to be positive on CRD. Ten children were positive to nMal d 1 for apple (value range, 1.10-40.59), 6 to rConr a 1 for hazelnut (1.53-11.97), 4 to rPru p 1 for peach (1.32-11.83). 6 to rAra h 8 for peanut (1.20-8.12), 6 to nAct d 8 for kiwi (0.85-3.32), 4 to rBet v 1 for birch (2.49-54.28), and 3 to rAln g 1 for alder (2.32-5.74). Six children were positive to nPru p 3 for peach (1.45-18.77), 4 to rCor a 8 for hazelnut (2.56-9.19), 2 to nArt v 3 for mugwort (3.40-7.42), and 3 to rBet v2 to profilin of birch (2.56-17.46). Ten children with AIU were positive to multiple component proteins. For hazelnut, 5 children were positive to PR-10 (rConr a 1) and nsLTP (rConr a 1). For peach, 3 children were positive to PR-10 (rPru p 1) and nsLTP (nPru p 3).
CONCLUSION
IgE sensitization to PR-10 or nsLTP may be allergen components for AIU in childhood.

Keyword

Urticaria; Allergen; Diagnosis

MeSH Terms

Allergens
Alnus
Arachis
Artemisia
Betula
Child*
Corylus
Diagnosis
Humans
Immunoglobulin E
Profilins
Prunus persica
Urticaria*
Allergens
Immunoglobulin E
Profilins

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