J Liver Cancer.  2017 Sep;17(2):117-125. 10.17998/jlc.17.2.117.

Non-alcoholic Fatty Liver Disease and Hepatocellular Carcinoma

• Oh H
• Jun DW

• KMID: 2396566
• DOI: http://doi.org/10.17998/jlc.17.2.117

Abstract

Hepatocellular carcinoma (HCC) is one of the most common life-threatening cancers worldwide. Recently, many patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have progressed to HCC even in the absence of cirrhosis. As the morbidity of metabolic syndrome increases, the proportion of HCC associated with NAFLD is expected to increase gradually. A new mechanism for the development of HCC in NAFLD has been identified; Diabetes mellitus, insulin resistance, obesity, lipotoxicity, gut dysbiosis are risk factors. Inflammatory cytokines such as adipokines, leptin, tumor necrosis factor-α, interlukin-8, nuclear factor-κB constitute dysplasia-carcinoma sequence. At the time of diagnosis, NAFLD/NASH related HCC tend to progress to larger and in advanced tumor-node-metastasis stages compared to viral hepatitis related HCC. But there are no guidelines for early detection of NAFLD-related HCC. So, it is essential to study the screening program for the early detection of NAFLD-related HCC and precise methods for NAFLD.

Keyword

Hepatocellular carcinoma; Non-alcoholic fatty liver disease; Metabolic syndrome X

MeSH Terms

Adipokines
Carcinoma, Hepatocellular*
Cytokines
Diabetes Mellitus
Diagnosis
Dysbiosis
Fatty Liver
Fibrosis
Hepatitis
Humans
Insulin Resistance
Leptin
Mass Screening
Metabolic Syndrome X
Necrosis
Non-alcoholic Fatty Liver Disease*
Obesity
Risk Factors
Adipokines
Cytokines
Leptin