Arch Aesthetic Plast Surg.  2017 Oct;23(3):135-142. 10.14730/aaps.2017.23.3.135.

The Feasibility of Platelet-Rich Fibrin Matrix Filler in a Nude Mouse Model

• Jeon HJ
• Kim DK
• Lee JW
• Choi KY
• Chung HY
• Cho BC
• Shin JH
• Lee SR
• Yang JD

• KMID: 2394319
• DOI: http://doi.org/10.14730/aaps.2017.23.3.135

Abstract

BACKGROUND
In contrast to fillers made from artificial substances, platelet-rich fibrin matrix (PRFM) filler does not cause hypersensitivity reactions or foreign body reactions. PRFM is also highly accessible in terms of cost. Hence, in this study, the efficacy of PRFM for soft tissue augmentation and volume maintenance was evaluated in an animal experiment.
METHODS
Twenty nude mice were injected with hyaluronic acid filler, fibrin glue, PRFM filler, and normal saline (control). The remaining volume was measured 4 times over the course of 8 weeks using the volumetric taping bowl method and magnetic resonance imaging.
RESULTS
All nude mice survived and showed no signs of infection, such as erythema or edematous changes, during the study period. Migration of the injected substance was not detected at 2, 4, or 8 weeks after the procedure. The remaining volumes of normal saline at 2, 4, and 8 weeks were 10.50%, 2.00%, and 0.00%; fibrin glue, 20.50%, 9.00%, and 2.50%; hyaluronic acid filler, 82.00%, 35.00%, and 17.33%; and PRFM filler, 70.31%, 26.75%, and 14.37%, respectively.
CONCLUSIONS
PRFM filler had a high soft-tissue filling capacity compared with the control. It also showed a similar effect to hyaluronic acid filler. Thus, PRFM filler could be a good alternative for correcting soft-tissue deficits.

Keyword

Cosmetic techniques; Fibrin; Hyaluronic acid; Hypersensitivity; Platelet-rich plasma

MeSH Terms

Animal Experimentation
Animals
Cosmetic Techniques
Erythema
Fibrin Tissue Adhesive
Fibrin*
Foreign Bodies
Hyaluronic Acid
Hypersensitivity
Magnetic Resonance Imaging
Methods
Mice
Mice, Nude*
Platelet-Rich Plasma
Fibrin
Fibrin Tissue Adhesive
Hyaluronic Acid