Exp Mol Med.
2017 Sep;49(9):e378. 10.1038/emm.2017.208.
A focus on extracellular Ca²⺠entry into skeletal muscle
- Affiliations
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- 1Department of Pharmacology, College of Medicine, Seoul National University, Seoul, Republic of Korea.
- 2Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
- 3Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
- 4Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. ehui@catholic.ac.kr
- KMID: 2394309
- DOI: http://doi.org/10.1038/emm.2017.208
Abstract
- The main task of skeletal muscle is contraction and relaxation for body movement and posture maintenance. During contraction and relaxation, Ca²âº in the cytosol has a critical role in activating and deactivating a series of contractile proteins. In skeletal muscle, the cytosolic Ca²âº level is mainly determined by Ca²âº movements between the cytosol and the sarcoplasmic reticulum. The importance of Ca²âº entry from extracellular spaces to the cytosol has gained significant attention over the past decade. Store-operated Ca²âº entry with a low amplitude and relatively slow kinetics is a main extracellular Ca²âº entryway into skeletal muscle. Herein, recent studies on extracellular Ca²âº entry into skeletal muscle are reviewed along with descriptions of the proteins that are related to extracellular Ca²âº entry and their influences on skeletal muscle function and disease.
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