Korean J Med.  2017 Aug;92(4):419-423. 10.3904/kjm.2017.92.4.419.

Community-onset Necrotizing Fasciitis Caused by Extended-spectrum Beta-lactamase-producing Eshcerichia coli

• Jang JH
• Kim CW
• Kim SY
• Park YJ
• Seo MJ
• Kim SA

• KMID: 2392353
• DOI: http://doi.org/10.3904/kjm.2017.92.4.419

Abstract

Necrotizing fasciitis (NF) is an uncommon but fatal infectious disorder that rapidly destroys connective tissue, causing extensive necrosis, severe sepsis, multiple organ failure, and death. NF is more common in patients with comorbid medical conditions. Most NF is caused by bacteria extending from localized skin infections, or remote bacteremia. Escherichia coli (E. coli) has been isolated from polymicrobial NF, but is rarely causative of monomicrobial NF. In addition, NF attributable to community-onset, extended- spectrum beta-lactamase (ESBL)-producing E. coli has not been described previously. As ESBL-producing E. coli are becoming significant pathogens of community-acquired infections worldwide, we report an exceptional case of community-onset NF attributable to monomicrobial ESBL-producing E. coli in a patient with liver cirrhosis.

Keyword

Fasciitis, Necrotizing; Beta-lactamases; Escherichia coli; Community-acquired Infections

MeSH Terms

Bacteremia
Bacteria
beta-Lactamases
Community-Acquired Infections
Connective Tissue
Escherichia coli
Fasciitis, Necrotizing*
Humans
Liver Cirrhosis
Multiple Organ Failure
Necrosis
Sepsis
Skin
beta-Lactamases