Clin Exp Vaccine Res.  2013 Jan;2(1):46-52.

Current status of registry of vaccine clinical trials conducted by Korean investigators in ClinicalTrials.gov, database of US National Institutes of Health

• Cho J
• Kim BB
• Bae CW
• Cha SH

Abstract

PURPOSE
PubMed is not only includes international medical journals but also has a registration site for the ongoing clinical trials, such as ClinicalTrials.gov, under the supervision of US National Institutes of Health. We analyzed current status of vaccine clinical trials conducted by Korean investigators in database of ClinicalTrial.gov.
MATERIALS AND METHODS
As of October 2012, there are total of 72 trials found on registry of vaccine clinical trials conducted by Korean investigators in database of ClinicalTrial.gov. These trials were analyzed and classified by conditions of vaccine clinical trials, biologicals or drugs used in vaccine clinical trials, status of proceeding research, and list of sponsor and collaborators.
RESULTS
Total 72 trials of vaccine clinical trials conducted by Korean investigators are classified by groups of infection (64 trials), cancer (4 trials), and others (4 trials). Infections group shown are as follows: poliomyelitis, pertussis, diphtheria, tetanus, and Haemophilus influenzae type b (10), influenza (9), human papillomavirus infection (8), pneumococcal vaccine (6), herpes zoster (4), smallpox (4), hepatitis B (4), etc. One trial of each in lung cancer, breast cancer, prostate cancer, and colorectal cancer are shown in cancer group. One trial of each in Crohn's disease, ulcerative colitis, renal failure, and rheumatoid arthritis are shown in other group.
CONCLUSION
Vaccine clinical trials conducted by Korean investigators in ClinicalTrial.gov reflects the current status of Korean research on vaccine clinical trials at the international level and can indicate research progress. It is hoped that this aids the development of future vaccine clinical trials in Korea.

Keyword

Vaccines; Clinical trial; Database; ClinicalTrials.gov; US National Institutes of Health

MeSH Terms

Arthritis, Rheumatoid
Breast Neoplasms
Colitis, Ulcerative
Colorectal Neoplasms
Crohn Disease
Diphtheria
Haemophilus influenzae type b
Hepatitis B
Herpes Zoster
Humans
Influenza, Human
Korea
Lung Neoplasms
National Institutes of Health (U.S.)
Organization and Administration
Papillomavirus Infections
Poliomyelitis
Prostatic Neoplasms
Renal Insufficiency
Research Personnel
Smallpox
Tetanus
Vaccines
Whooping Cough
Vaccines

Reference

1. Korean Association of Medical Journals Editor. KoreaMed [Internet]. c2012. cited 2012 Oct 30. Seoul: Korean Association of Medical Journal Editors;Available from: http://www.koreamed.org.

2. US National Library of Medicine. PubMed [Internet]. c2012. cited 2012 Oct 30. Bethesda: US National Library of Medicine;Available from: http://www.ncbi.nlm.nih.gov/sites/entrez/.

3. US National Institutes of Health. ClinicalTrials.gov [Internet]. c2012. cited 2012 Oct 30. Bethesda: US National Institutes of Health;Available from: http://clinicaltrials.gov/.