Infect Chemother.  2013 Mar;45(1):22-31.

Antimicrobial Resistance in Asia: Current Epidemiology and Clinical Implications

• Kang CI
• Song JH

Abstract

Antimicrobial resistance has become one of the most serious public health concerns worldwide. Although circumstances may vary by region or country, it is clear that some Asian countries are epicenters of resistance, having seen rapid increases in the prevalence of antimicrobial resistance of major bacterial pathogens. In these locations, however, the public health infrastructure to combat this problem is very poor. The prevalence rates of methicillin-resistant Staphylococcus aureus (MRSA), macrolide-resistant Streptococcus pneumoniae, and multidrug-resistant enteric pathogens are very high due to the recent emergence of extremely drug-resistant gram-negative bacilli in Asia. Because antimicrobial options for these pathogens are extremely limited, infections caused by antimicrobial-resistant bacteria are often associated with inappropriate antimicrobial therapy and poor clinical outcomes. Physicians should be aware of the current epidemiological status of resistance and understand the appropriate use of antimicrobial agents in clinical practice. This review focuses on describing the epidemiology and clinical implications of antimicrobial-resistant bacterial infections in Asian countries.

Keyword

Antimicrobial resistance; Epidemiology; Bacterial infections; Asia

MeSH Terms

Anti-Infective Agents
Asia
Asian Continental Ancestry Group
Bacteria
Bacterial Infections
Drug Resistance, Microbial*
Humans
Methicillin-Resistant Staphylococcus aureus
Prevalence
Public Health
Streptococcus pneumoniae
Anti-Infective Agents

Figure

• 

  Figure 1 Prevalence of methicillin resistance among S. aureus isolates.Some Asian countries have shown the highest prevalence rates of MRSA.

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  Figure 2 Prevalence of ESBL-producers among E. coli and K. pneumoniae isolates causing urinary tract infections by country in the Asia-Pacific region, adopted from reference [44].

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  Figure 3 Susceptibility to imipenem among isolates of P. aeruginosa and A. baumannii obtained from patients with intra-abdominal infections in selected countries in the Asia-Pacific region, adopted from reference [70].

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