J Periodontal Implant Sci.  2016 Feb;46(1):46-56. 10.5051/jpis.2016.46.1.46.

Effects of a mouthwash containing potassium nitrate, sodium fluoride, and cetylpyridinium chloride on dentin hypersensitivity: a randomized, double-blind, placebo-controlled study

• Hong JY
• Lim HC
• Herr Y

• KMID: 2391729
• DOI: http://doi.org/10.5051/jpis.2016.46.1.46

Abstract

PURPOSE
We evaluated the efficacy of a mouthwash containing potassium nitrate (KNO3) as its main component, along with sodium fluoride (NaF) and cetylpyridinium chloride (CPC). The primary endpoint was the relief of dentin hypersensitivity (DH) against the cold stimuli. The effects on other DH tests and periodontal inflammation were also evaluated.
METHODS
We used a single-center, double-blind, placebo-controlled, randomized design. A total of 82 patients with DH (40 in the test group, 42 placebo controls) were analyzed using visual analog scales (VASs) for a cold test, a tactile test, a compressive air test, and self-reported pain during daily activities, as well as clinical parameters including plaque index, gingival index, modified sulcular bleeding index (mSBI), gingival recession, and probing depth, which were collected at baseline and after four and six weeks of mouthwash use.
RESULTS
VAS scores for cold sensations, tactile sensations, the compressive air test, and self-reported pain significantly decreased from baseline during the six weeks in both groups (P<0.01), and no significant differences between the groups were found. In male patients (10 in the test group and 7 in the control group), both groups showed significant reductions in VAS scores for the cold test over the six weeks, and greater reductions were found in the test group than in the control group between four and six weeks (P=0.01) and between baseline and six weeks (P<0.01). In addition, the mSBI in the test group significantly decreased from baseline during the six weeks (P<0.01), and the changes at four and six weeks from baseline were significantly greater in the test group compared to the control group (P=0.03 and P=0.02, respectively).
CONCLUSIONS
A mouthwash containing a mixture of KNO3, NaF, and CPC reduced DH and gingival inflammation, however, the efficacy was comparable to the control group.

Keyword

Dentin hypersensitivity; Mouthwash; Potassium nitrate; Sodium fluoride; Cetylpyridinium chloride; Gingival inflammation

MeSH Terms

Cetylpyridinium*
Dentin Sensitivity*
Dentin*
Double-Blind Method
Gingival Recession
Hemorrhage
Humans
Inflammation
Male
Periodontal Index
Potassium*
Sensation
Sodium Fluoride*
Sodium*
Visual Analog Scale
Cetylpyridinium
Potassium
Sodium
Sodium Fluoride

Figure

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  Figure 1 Diagram of patient enrollment.

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