Genomics Inform.  2014 Dec;12(4):216-224. 10.5808/GI.2014.12.4.216.

Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort Study

• Jeong HH
• Sohn KA

• KMID: 2391499
• DOI: http://doi.org/10.5808/GI.2014.12.4.216

Abstract

Gastritis is a common but a serious disease with a potential risk of developing carcinoma. Helicobacter pylori infection is reported as the most common cause of gastritis, but other genetic and genomic factors exist, especially single-nucleotide polymorphisms (SNPs). Association studies between SNPs and gastritis disease are important, but results on epistatic interactions from multiple SNPs are rarely found in previous genome-wide association (GWA) studies. In this study, we performed computational GWA case-control studies for gastritis in Korea Associated Resource (KARE) data. By transforming the resulting SNP epistasis network into a gene-gene epistasis network, we also identified potential gene-gene interaction factors that affect the susceptibility to gastritis.

Keyword

gastritis; genome-wide association study; KARE; mutual information; relevance network; single-nucleotide polymorphism

MeSH Terms

Case-Control Studies
Cohort Studies*
Gastritis*
Genome-Wide Association Study
Helicobacter pylori
Korea
Polymorphism, Single Nucleotide