Genomics Inform.  2014 Dec;12(4):216-224. 10.5808/GI.2014.12.4.216.

Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort Study

Affiliations
  • 1Department of Information and Computer Engineering, Ajou University, Suwon 443-749, Korea. kasohn@ajou.ac.kr

Abstract

Gastritis is a common but a serious disease with a potential risk of developing carcinoma. Helicobacter pylori infection is reported as the most common cause of gastritis, but other genetic and genomic factors exist, especially single-nucleotide polymorphisms (SNPs). Association studies between SNPs and gastritis disease are important, but results on epistatic interactions from multiple SNPs are rarely found in previous genome-wide association (GWA) studies. In this study, we performed computational GWA case-control studies for gastritis in Korea Associated Resource (KARE) data. By transforming the resulting SNP epistasis network into a gene-gene epistasis network, we also identified potential gene-gene interaction factors that affect the susceptibility to gastritis.

Keyword

gastritis; genome-wide association study; KARE; mutual information; relevance network; single-nucleotide polymorphism

MeSH Terms

Case-Control Studies
Cohort Studies*
Gastritis*
Genome-Wide Association Study
Helicobacter pylori
Korea
Polymorphism, Single Nucleotide
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