- Impact of Evolutionary Changes in Nonalcoholic Fatty Liver Disease on Lung Function Decline
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Lee HW, Chung GE, Koo BK, Sim H, Choi M, Lee DH, Choi SH, Kwak SH, Kim DK, Kim W, obotITEoN(c
- KMID: 2538165
- Gut Liver.
- 2023 Jan;17(1):139-149.
- doi: 10.5009/gnl210545
Background/Aims: A relationship between fatty liver and lung function impairment has been identified, and both are independently associated with metabolic dysfunction. However, the temporal relationship between changes in fatty liver... -
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- The genetics of obesity: A narrative review
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Sohn YB
- KMID: 2538087
- Precis Future Med.
- 2022 Dec;6(4):226-232.
- doi: 10.23838/pfm.2022.00156
Monogenic obesity is a rare, early-onset, and severe form of obesity that has a Mendelian inheritance pattern, high penetrance, and large genetic effect. In contrast, common polygenic obesity is more... -
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- Multidimensional Early Prediction Score for Drug-Resistant Epilepsy
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Kang KW, Cho YW, Lee SK, Jung KY, Kim JH, Kim DW, Lee SA, Hong SB, Na IS, Lee SH, Baek WK, Choi SY, Kim MK
- KMID: 2532700
- J Clin Neurol.
- 2022 Sep;18(5):553-561.
- doi: 10.3988/jcn.2022.18.5.553
Background and Purpose Achieving favorable postoperative outcomes in patients with drug-resistant epilepsy (DRE) requires early referrals for preoperative examinations. The purpose of this study was to investigate the possibility of... -
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- MPI-GWAS: a supercomputing-aided permutation approach for genome-wide association studies
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Paik H, Cho Y, Cho SB, Kwon OK
- KMID: 2527957
- Genomics Inform.
- 2022 Mar;20(1):e14.
- doi: 10.5808/gi.22001
Permutation testing is a robust and popular approach for significance testing in genomic research that has the advantage of reducing inflated type 1 error rates; however, its compu-tational cost is... -
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- Regulation of Pancreatic β-Cell Mass by Gene-Environment Interaction
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Asahara Si, Inoue H, Kido Y
- KMID: 2525124
- Diabetes Metab J.
- 2022 Jan;46(1):38-48.
- doi: 10.4093/dmj.2021.0045
The main pathogenic mechanism of diabetes consists of an increase in insulin resistance and a decrease in insulin secretion from pancreatic β-cells. The number of diabetic patients has been increasing... -
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- Prediction of clinically significant prostate cancer using polygenic risk models in Asians
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Song SH, Kim E, Woo E, Kwon E, Yoon S, Kim JK, Lee H, Oh JJ, Lee S, Hong SK, Byun SS
- KMID: 2524272
- Investig Clin Urol.
- 2022 Jan;63(1):42-52.
- doi: 10.4111/icu.20210305
Purpose: To develop and evaluate the performance of a polygenic risk score (PRS) constructed in a Korean male population to predict clinically significant prostate cancer (csPCa). Materials and Methods: Total 2,702... -
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- Absolute Neutrophil Count after the First Chemotherapy Cycle as a Surrogate Marker for Treatment Outcomes in Patients with Neuroblastoma
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Lee JW, Bae JS, Kim JH, Cho HW, Ju HY, Yoo KH, Koo HH, Woo Sy, Kim S, Sung KW
- KMID: 2524607
- Cancer Res Treat.
- 2022 Jan;54(1):259-268.
- doi: 10.4143/crt.2021.010
Purpose We performed this study to determine whether the degree of neutropenia after the first chemotherapy cycle can be used as a surrogate marker of individual susceptibility to chemotherapeutic agents... -
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- Validation and genetic heritability estimation of known type 2 diabetes related variants in the Korean population
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Jang HM, Hwang MY, Kim BJ, Kim YJ
- KMID: 2524328
- Genomics Inform.
- 2021 Dec;19(4):e37.
- doi: 10.5808/gi.21071
Genome-wide association studies (GWASs) facilitated the discovery of countless disease-associated variants. However, GWASs have mostly been conducted in European ancestry samples. Recent studies have reported that these European-based association results... -
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- Unveiling Genetic Variants Underlying Vitamin D Deficiency in Multiple Korean Cohorts by a Genome-Wide Association Study
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Kim YA, Yoon JW, Lee Y, Choi HJ, Yun JW, Bae E, Kwon SH, Ahn SE, Do AR, Jin H, Won S, Park DJ, Shin CS, Seo JH
- KMID: 2523488
- Endocrinol Metab.
- 2021 Dec;36(6):1189-1200.
- doi: 10.3803/EnM.2021.1241
Background: Epidemiological data have shown that vitamin D deficiency is highly prevalent in Korea. Genetic factors influencing vitamin D deficiency in humans have been studied in Europe but are less... -
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- Clinical, Radiographic, and Genetic Analyses in a Population-Based Cohort of Adult Spinal Deformity in the Older Population
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Shin JJ, Kim B, Kang J, Choi J, Moon BJ, Ryu DS, Yoon SH, Chin DK, Lee JK, Kim KN, Ha Y
- KMID: 2520970
- Neurospine.
- 2021 Sep;18(3):608-617.
- doi: 10.14245/ns.2142544.272
Objective: This study aimed to identify the sagittal parameters associated with health-related quality of life and genetic variations that increase the risk of adult spinal deformity (ASD) onset in the... -
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- Polygenic Risk Scores for Bipolar Disorder in Korean Populations in Comparison to European Populations
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Choi MJ, Lee DB, Cho Y, Cho EY, Hong KS, Baek JH
- KMID: 2519851
- J Korean Neuropsychiatr Assoc.
- 2021 Aug;60(3):167-173.
- doi: 10.4306/jknpa.2021.60.3.167
Objectives This study examined whether the polygenic risk score (PRS) calculated from the most recent genome-wide association study for bipolar disorder (BD) of European ancestry patients is significantly associated with... -
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- Functional annotation of lung cancer‒associated genetic variants by cell type‒specific epigenome and long-range chromatin interactome
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Lee AJ, Jung I
- KMID: 2514707
- Genomics Inform.
- 2021 Mar;19(1):e3.
- doi: 10.5808/gi.20073
Functional interpretation of noncoding genetic variants associated with complex human diseases and traits remains a challenge. In an effort to enhance our understanding of common germline variants associated with lung... -
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- Harnessing genome-wide association studies to minimize adverse radiation-induced side effects
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Benitez CM, Knox SJ
- KMID: 2509948
- Radiat Oncol J.
- 2020 Dec;38(4):226-235.
- doi: 10.3857/roj.2020.00556
Radiotherapy is used as definitive treatment in approximately two-thirds of all cancers. However, like any treatment, radiation has significant acute and long-term side effects including secondary malignancies. Even when similar... -
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- Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults
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Kong SH, Yoon JW, Kim JH, Park J, Choi J, Lee JH, Hong AR, Cho NH, Shin CS
- KMID: 2511007
- Endocrinol Metab.
- 2020 Dec;35(4):801-810.
- doi: 10.3803/EnM.2020.735
Background: As the genetic variants of trabecular bone microarchitecture are not well-understood, we performed a genome-wide association study to identify genetic determinants of bone microarchitecture analyzed by trabecular bone score... -
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- Comparison of Polygenic Risk for Schizophrenia between European and Korean Populations
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Lee J, Lee D, Cho EY, Baek JH, Hong KS
- KMID: 2508354
- Korean J Schizophr Res.
- 2020 Oct;23(2):65-70.
- doi: 10.16946/kjsr.2020.23.2.65
Objectives: This study aimed to explore whether common genetic variants that confer the risk of schizophrenia have similar effects between Korean and European ancestries using the polygenic risk score (PRS)... -
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- Insight into the pathogensis of polycystic ovarian syndrome
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Jung YW, Lee GH, Han YJ, Cha DH
- KMID: 2503604
- J Genet Med.
- 2020 Jun;17(1):1-10.
- doi: 10.5734/JGM.2020.17.1.1
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women, which is characterized by the oligo/ anovulation, hyperandrogenism (HA) and polycystic ovarian morphology which are diagnostic criteria. PCOS... -
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- HisCoM-PCA: software for hierarchical structural component analysis for pathway analysis based using principal component analysis
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Jiang N, Lee S, Park T
- KMID: 2501331
- Genomics Inform.
- 2020 Mar;18(1):e11.
- doi: 10.5808/GI.2020.18.1.e11
In genome-wide association studies, pathway-based analysis has been widely performed to enhance interpretation of single-nucleotide polymorphism association results. We proposed a novel method of hierarchical structural component model (HisCoM) for... -
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- Two-sample Mendelian randomization study for schizophrenia and breast cancer
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Kim S, Kim K, Myung W, Lee H, Kim H, Kim DK, Won HH
- KMID: 2501510
- Precis Future Med.
- 2020 Mar;4(1):21-30.
- doi: 10.23838/pfm.2019.00093
Purpose: The purpose of this study was to investigate whether the risk of schizophrenia is causally associated with the risk of breast cancer. Methods: Bidirectional two-sample Mendelian randomization (TSMR) was performed... -
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- Genetics of Treatment Outcomes in Major Depressive Disorder: Present and Future
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Fabbri C, Serretti A
- KMID: 2502121
- Clin Psychopharmacol Neurosci.
- 2020 Feb;18(1):1-9.
- doi: 10.9758/cpn.2020.18.1.1
Pharmacogenetic testing is a useful and increasingly widespread tool to assist in antidepressant prescription. More than ten antidepressants (including tricyclics, selective serotonin reuptake inhibitors and venlafaxine) have already genetic biomarkers... -
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- Genetic Architecture of Circulating Very-Long-Chain (C24:0 and C22:0) Ceramide Concentrations
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Cresci S, Zhang R, Yang Q, Duncan MS, Xanthakis , Jiang X, Vasan RS, Schaffer J, Peterson L
- KMID: 2470809
- J Lipid Atheroscler.
- 2020 Jan;9(1):172-183.
- doi: 10.12997/jla.2020.9.1.172
OBJECTIVE: Total ceramide concentrations are linked with increased insulin resistance and cardiac dysfunction. However, recent studies have demonstrated that plasma concentrations of specific very-long-chain fatty ceramides (C24:0 and C22:0) are... -
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