Korean J Dermatol.  2017 Aug;55(7):445-448.

Levofloxacin-induced Fixed Drug Eruption: A Case Report

Affiliations
  • 1Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea. dermakim@hanyang.ac.kr

Abstract

Fixed drug eruptions (FDEs) are characterized by the presence of site-specific recurrence of a solitary or multiple, well-circumscribed, erythematous macules or patches that recur with each exposure to a particular medication. Several drugs including non-steroidal anti-inflammatory drugs, non-opioid analgesics, sedatives, anticonvulsants, sulfonamides, and tetracycline have been associated with an increased risk of inducing FDE. A 45-year-old woman with known history of levofloxacin use presented with erythematous patches on her face and left forearm. Although a patch test to levofloxacin showed a negative reaction, intradermal tests to assess hypersensitivity to levofloxacin were positive, and she was diagnosed with levofloxacin-induced FDE. Her antibiotic was switched to moxifloxacin, which she tolerated well. Moxifloxacin did not show cross-reactivity. Because of the widespread use of fluoroquinolones, it is important to consider these as possible etiological agents in cases of FDE. We describe a case of FDE diagnosed using positive intradermal tests to detect sensitivity to levofloxacin.

Keyword

Fixed drug eruption; Levofloxacin

MeSH Terms

Analgesics
Anticonvulsants
Drug Eruptions*
Female
Fluoroquinolones
Forearm
Humans
Hypersensitivity
Hypnotics and Sedatives
Intradermal Tests
Levofloxacin
Middle Aged
Patch Tests
Recurrence
Sulfonamides
Tetracycline
Analgesics
Anticonvulsants
Fluoroquinolones
Hypnotics and Sedatives
Sulfonamides
Tetracycline
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