J Gastric Cancer.  2016 Dec;16(4):215-220. 10.5230/jgc.2016.16.4.215.

Risk Factors and Tumor Recurrence in pT1N0M0 Gastric Cancer after Surgical Treatment

• Choi HJ
• Kim SM
• An JY
• Choi MG
• Lee JH
• Sohn TS
• Bae JM
• Kim S

• KMID: 2389846
• DOI: http://doi.org/10.5230/jgc.2016.16.4.215

Abstract

PURPOSE
This study aimed to evaluate the rate, patterns, and risk factors associated with tumor recurrence in patients with T1N0 gastric cancer.
MATERIALS AND METHODS
The medical records of 8,753 patients with pathological T1N0M0 gastric cancer who underwent gastrectomy between 1994 and 2014 at Sungkyunkwan University School of Medicine were examined.
RESULTS
Among the 8,753 patients, 95 patients (1.1%) experienced tumor recurrence; this included 31 remnant, 27 hematogenous, 9 lymph nodal, 5 peritoneal, and 23 multiple-site recurrences. When patients were divided into two groups according to the presence of tumor recurrence, the following characteristics were higher in the recurrence group than in the non-recurrence group: older age (≥65 years), male gender, undifferentiated histology, submucosal invasion, and venous invasion. In multivariate analysis, older age, male gender, tumor depth (sm2 and sm3 invasion), and venous invasion were independent risk factors for tumor recurrence. The recurrence rates were 0.7% in patients with less than two risk factors, 1.7% in those with two risk factors, 3.0% in those with three risk factors, and 6.3% in those with four risk factors (P<0.001).
CONCLUSIONS
Although tumor recurrence is rare in pT1N0M0 gastric cancer, some patients with certain risk factors demonstrate an increased rate of tumor recurrence. Careful follow-up is required for patients with three or four risk factors.

Keyword

Stomach neoplasms; Recurrence; Risk factors

MeSH Terms

Follow-Up Studies
Gastrectomy
Humans
Male
Medical Records
Multivariate Analysis
Recurrence*
Risk Factors*
Stomach Neoplasms*

Figure

• 

  Fig. 1 Recurrence-free survival curves for T1N0MO early gastric cancer according to the number of risk factors (Kaplan-Meier analysis with log-rank test).

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