J Korean Surg Soc.  2010 Jul;79(1):35-42. 10.4174/jkss.2010.79.1.35.

Clinicopathological Analysis of Recurrence in Stage 1 Gastric Cancer

• Baik SH
• Yang SI
• Shin YM

• KMID: 1455485
• DOI: http://doi.org/10.4174/jkss.2010.79.1.35

Abstract

PURPOSE
Recently, diagnosis of stage 1 gastric cancer has increased in number and prognosis is excellent when proper treatment is done. However, some patients have recurrence and their prognosis is poor. Thus, we investigated the risk factors of recurrence in stage 1 gastric cancer patients.
METHODS
From January 2004 to December 2008, a total of 1,241 number patients were operated on for stage 1 gastric cancer at the Department of General Surgery, Kosin University Gospel Hospital. We reviewed the characteristics of all patients retrospectively and compared them to recurred group (n=24) and non-recurred group (n=1,114). We analyzed the risk factors associated with recurrence.
RESULTS
Twenty-four patients with stage 1 gastric cancer were recurred after radical gastrectomy. Recurrence rate was 2.05%. The most common pattern of recurrence was hematogenous (41.7%), and lymphatic (20.8%), peritoneal seeding (16.7%), combined form (12.5%), and locoregional (8.3%). Five-year survival rate was 50.08% of recurrence group. Of clinicopathological factors, depth of invasion, lymph node metastasis, lymphatic involvement and tumor marker were statistically significant between recurred and other group.
CONCLUSION
In this study, tumor marker, tumor depth, node status, lymphatic channel involvement were possible risk factors of recurrence for stage 1 gastric cancer. More intensive follow up and care is needed for those with such risk factors.

Keyword

Stage 1 gastric cancer; Recurrence; Risk factor

MeSH Terms

Follow-Up Studies
Gastrectomy
Humans
Lymph Nodes
Lymphatic Metastasis
Prognosis
Recurrence
Retrospective Studies
Risk Factors
Seeds
Stomach Neoplasms
Survival Rate

Figure

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  Fig. 1 Survival curves of recur and non-recur group.

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  Fig. 2 Survival curves by recurrence pattern.

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