Korean Circ J.  2015 May;45(3):242-244. 10.4070/kcj.2015.45.3.242.

The Relationship between Spontaneous Multi-Vessel Coronary Artery Dissection and Celiac Disease

Affiliations
  • 1Department of Cardiology, Antalya Education and Research Hospital, Antalya, Turkey. dr.nermin@mynet.com

Abstract

Celiac disease (CD) is an immune-mediated enteropathy involving the small intestines. Genetic and environmental risk factors as well as autoimmunity have been linked to its etiology. Studies have shown that coronary artery disease, autoimmune myocarditis, arrhythmias and premature atherosclerosis are more prevalent in individuals with CD compared to individuals without the disease. In this case report a young male patient with CD presented with acute myocardial infarction with spontaneous coronary artery dissections of two vessels. To the best of our knowledge, this is the first case report of spontaneous multi-vessel coronary artery dissection in a patient with CD.

Keyword

Celiac disease; Homocysteine; Dissection

MeSH Terms

Arrhythmias, Cardiac
Atherosclerosis
Autoimmunity
Celiac Disease*
Coronary Artery Disease
Coronary Vessels*
Homocysteine
Humans
Intestine, Small
Male
Myocardial Infarction
Myocarditis
Risk Factors
Homocysteine

Figure

  • Fig. 1 Left coronary angiogram demonstrating coronary dissection in the left anterior descending artery (arrows).

  • Fig. 2 Right coronary angiogram showing the dissection in the right coronary artery (arrows).


Reference

1. Ludvigsson JF, Leffler DA, Bai JC, et al. The Oslo definitions for coeliac disease and related terms. Gut. 2013; 62:43–52.
2. Green PH, Cellier C. Celiac disease. N Engl J Med. 2007; 357:1731–1743.
3. Schuppan D. Current concepts of celiac disease pathogenesis. Gastroenterology. 2000; 119:234–242.
4. Collin P, Salmi J, Hällström O, et al. High frequency of coeliac disease in adult patients with type-I diabetes. Scand J Gastroenterol. 1989; 24:81–84.
5. Rustgi AK, Peppercorn MA. Gluten-sensitive enteropathy and systemic lupus erythematosus. Arch Intern Med. 1988; 148:1583–1584.
6. Frustaci A, Cuoco L, Chimenti C, et al. Celiac disease associated with autoimmune myocarditis. Circulation. 2002; 105:2611–2618.
7. Hering D, Piper C, Hohmann C, Schultheiss HP, Horstkotte D. [Prospective study of the incidence, pathogenesis and therapy of spontaneous, by coronary angiography diagnosed coronary artery dissection]. Z Kardiol. 1998; 87:961–970.
8. Najaf SM, Quraishi AR, Kazmi KA. Spontaneous multivessel coronary artery dissection associated with elevated homocysteine levels. J Coll Physicians Surg Pak. 2005; 15:108–109.
9. Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child. 1990; 65:909–911.
10. Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol. 1999; 11:1185–1194.
11. Srinivas M, Basumani P, Muthusamy R, Wheeldon N. Active inflammatory bowel disease and coronary artery dissection. Postgrad Med J. 2005; 81:68–70.
12. Ludvigsson JF, de Faire U, Ekbom A, Montgomery SM. Vascular disease in a population-based cohort of individuals hospitalised with coeliac disease. Heart. 2007; 93:1111–1115.
13. De Marchi S, Chiarioni G, Prior M, Arosio E. Young adults with coeliac disease may be at increased risk of early atherosclerosis. Aliment Pharmacol Ther. 2013; 38:162–169.
14. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med. 1998; 338:1042–1050.
15. Lim PO, Tzemos N, Farquharson CA, et al. Reversible hypertension following coeliac disease treatment: the role of moderate hyperhomocysteinaemia and vascular endothelial dysfunction. J Hum Hypertens. 2002; 16:411–415.
16. Kamran M, Guptan A, Bogal M. Spontaneous coronary artery dissection: case series and review. J Invasive Cardiol. 2008; 20:553–559.
17. Mathur M, Huda N, Cohen H, Parris T. Spontaneous right coronary artery dissection: a case of spontaneous resolution. JACC Cardiovasc Interv. 2014; 7:e9–e10.
18. Vrints CJ. Spontaneous coronary artery dissection. Heart. 2010; 96:801–808.
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