Ann Dermatol.  2017 Aug;29(4):462-470. 10.5021/ad.2017.29.4.462.

The Clinical Profile of Patients with Psoriasis in Korea: A Nationwide Cross-Sectional Study (EPI-PSODE)

Affiliations
  • 1Department of Dermatology, Korea University Guro Hospital, Seoul, Korea.
  • 2Department of Dermatology, The Catholic University of Korea, Bucheon St. Mary's Hospital, Bucheon, Korea.
  • 3Department of Dermatology, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
  • 4Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.
  • 5Department of Dermatology, Kyungpook National University Hospital, Daegu, Korea.
  • 6Department of Dermatology, Kyung Hee University Medical Center, Seoul, Korea.
  • 7Department of Dermatology, Keimyung University Dongsan Medical Center, Daegu, Korea.
  • 8Department of Dermatology, Kosin University College of Medicine, Busan, Korea.
  • 9Department of Dermatology, National Medical Center, Seoul, Korea.
  • 10Department of Dermatology, Dankook University Hospital, Cheonan, Korea.
  • 11Department of Dermatology, Catholic University of Daegu School of Medicine, Daegu, Korea.
  • 12Department of Dermatology, Dong-A University Hospital, Busan, Korea.
  • 13Department of Dermatology, Pusan National University School of Medicine, Busan, Korea.
  • 14Department of Dermatology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • 15Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 16Department of Dermatology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 17Department of Dermatology, Wonju Severance Christian Hospital, Wonju, Korea.
  • 18Department of Dermatology, Chonnam National University Hospital, Gwangju, Korea.
  • 19Department of Dermatology, Chonbuk National University Hospital, Jeonju, Korea.
  • 20Department of Dermatology, Chosun University Hospital, Gwangju, Korea.
  • 21Department of Dermatology, Chung-Ang University Hospital, Seoul, Korea.
  • 22Department of Dermatology, Chungbuk National University College of Medicine, Cheongju, Korea.
  • 23Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.
  • 24Department of Dermatology, Hanyang University Medical Center, Seoul, Korea.
  • 25Medical Affairs, Janssen Korea, Seoul, Korea.
  • 26Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. jhchoy@amc.seoul.kr

Abstract

BACKGROUND
Psoriasis is an immune-mediated, chronic inflammatory disease affecting multiple aspects of patients' lives. Its epidemiology varies regionally; however, nationwide epidemiologic data on psoriasis depicting profile of Korean patients has not been available to date.
OBJECTIVE
To understand nationwide epidemiologic characteristics and clinical features of adult patients with psoriasis visited university hospitals in Korea.
METHODS
This multicenter, non-interventional, cross-sectional study recruited 1,278 adult patients with psoriasis across 25 centers in Korea in 2013. Various clinical data including PASI, BSA, DLQI, SF-36 and PASE were collected.
RESULTS
A total of 1,260 patients completed the study (male:female=1.47:1). The mean age was 47.0 years with a distribution mostly in the 50s (24.9%). Early onset (<40 years) of psoriasis accounted for 53.9% of patients. The mean disease duration was 109.2 months; mean body mass index was 23.9 kg/m²; and 12.7% of patients had a family history of psoriasis. Plaque and guttate types of psoriasis accounted for 85.8% and 8.4%, respectively. Patients with PASI ≥10 accounted for 24.9%; patients with body surface area ≥10 were 45.9%. Patients with DLQI ≥6 accounted for 78.8%. Between PASI <10 and PASI ≥10 groups, significant difference was noted in age at diagnosis, disease duration, blood pressure, waist circumference of female, and treatment experiences with phototherapy, systemic agents, and biologics.
CONCLUSION
This was the first nationwide epidemiologic study of patients with psoriasis in Korea and provides an overview of the epidemiologic characteristics and clinical profiles of this patient population.

Keyword

Epidemiologic studies; Korea; Psoriasis

MeSH Terms

Adult
Biological Products
Blood Pressure
Body Mass Index
Body Surface Area
Cross-Sectional Studies*
Diagnosis
Epidemiologic Studies
Epidemiology
Female
Hospitals, University
Humans
Korea*
Phototherapy
Psoriasis*
Waist Circumference
Biological Products

Figure

  • Fig. 1 Age distribution of patient (A) and distribution of age at diagnosis (B).

  • Fig. 2 Disease severity classified by psoriasis area and severity index (PASI), body surface area (BSA), and dermatology life quality index (DLQI). Overall mean±standard deviation (SD) are presented below the title. Each n (%) of the classified group is presented.

  • Fig. 3 Psoriatic arthritis screening and evaluation (PASE). SD: standard deviation.


Cited by  2 articles

Recent medical therapy for psoriasis
Sang Woong Youn
J Korean Med Assoc. 2019;62(3):176-180.    doi: 10.5124/jkma.2019.62.3.176.

Usefulness of the Psoriatic Arthritis Screening and Evaluation Questionnaire to Monitor Disease Activity in Management of Patients with Psoriasis: Findings from the EPI-PSODE Study
Yong Beom Choe, Chul Jong Park, Dae Young Yu, Youngdoe Kim, Hyun Jeong Ju, Sang Woong Youn, Joo-Heung Lee, Byung Soo Kim, Seong Jun Seo, Seok-Kweon Yun, Joonsoo Park, Nack In Kim, Jai Il Youn, Seok-Jong Lee, Min-Geol Lee, Kwang Joong Kim, Young Suck Ro, Hae Jun Song, Bong Seok Shin, Sung Ku Ahn, Ji Yeoun Lee, Young Ho Won, Min Soo Jang, Ki Ho Kim, Myung Hwa Kim, Tae Yoon Kim, Jee-Ho Choi
Ann Dermatol. 2019;31(1):29-36.    doi: 10.5021/ad.2019.31.1.29.


Reference

1. Schön MP, Boehncke WH. Psoriasis. N Engl J Med. 2005; 352:1899–1912.
Article
2. Vernon MK, Revicki DA, Awad AG, Dirani R, Panish J, Canuso CM, et al. Psychometric evaluation of the Medication Satisfaction Questionnaire (MSQ) to assess satisfaction with antipsychotic medication among schizophrenia patients. Schizophr Res. 2010; 118:271–278.
Article
3. Na SJ, Jo SJ, Youn JI. Clinical study on psoriasis patients for past 30 years (1982-2012) in Seoul National University Hospital Psoriasis Clinic. J Dermatol. 2013; 40:731–735.
Article
4. Kawada A, Tezuka T, Nakamizo Y, Kimura H, Nakagawa H, Ohkido M, et al. A survey of psoriasis patients in Japan from 1982 to 2001. J Dermatol Sci. 2003; 31:59–64.
Article
5. Takahashi H, Nakamura K, Kaneko F, Nakagawa H, Iizuka H. Japanese Society for Psoriasis Research. Analysis of psoriasis patients registered with the Japanese Society for Psoriasis Research from 2002-2008. J Dermatol. 2011; 38:1125–1129.
Article
6. Ding X, Wang T, Shen Y, Wang X, Zhou C, Tian S, et al. Prevalence of psoriasis in China: a population-based study in six cities. Eur J Dermatol. 2012; 22:663–667.
Article
7. Tsai TF, Wang TS, Hung ST, Tsai PI, Schenkel B, Zhang M, et al. Epidemiology and comorbidities of psoriasis patients in a national database in Taiwan. J Dermatol Sci. 2011; 63:40–46.
Article
8. Henseler T, Christophers E. Disease concomitance in psoriasis. J Am Acad Dermatol. 1995; 32:982–986.
Article
9. Gelfand JM, Weinstein R, Porter SB, Neimann AL, Berlin JA, Margolis DJ. Prevalence and treatment of psoriasis in the United Kingdom: a population-based study. Arch Dermatol. 2005; 141:1537–1541.
10. Christophers E. Psoriasis--epidemiology and clinical spectrum. Clin Exp Dermatol. 2001; 26:314–320.
11. Gudjonsson JE, Elder JT. Psoriasis: epidemiology. Clin Dermatol. 2007; 25:535–546.
Article
12. Lin XR. Psoriasis in China. J Dermatol. 1993; 20:746–755.
Article
13. Jacobi A, Langenbruch A, Purwins S, Augustin M, Radtke MA. Prevalence of obesity in patients with psoriasis: results of the national study PsoHealth3. Dermatology. 2015; 231:231–238.
Article
14. Herron MD, Hinckley M, Hoffman MS, Papenfuss J, Hansen CB, Callis KP, et al. Impact of obesity and smoking on psoriasis presentation and management. Arch Dermatol. 2005; 141:1527–1534.
Article
15. Kim CR, Lee JH. An observational study on the obesity and metabolic status of psoriasis patients. Ann Dermatol. 2013; 25:440–444.
Article
16. Ferrándiz C, Pujol RM, García-Patos V, Bordas X, Smandía JA. Psoriasis of early and late onset: a clinical and epidemiologic study from Spain. J Am Acad Dermatol. 2002; 46:867–873.
Article
17. Sampogna F, Gisondi P, Melchi CF, Amerio P, Girolomoni G, Abeni D. Prevalence of symptoms experienced by patients with different clinical types of psoriasis. Br J Dermatol. 2004; 151:594–599.
Article
18. Fan X, Yang S, Sun LD, Liang YH, Gao M, Zhang KY, et al. Comparison of clinical features of HLA-Cw*0602-positive and -negative psoriasis patients in a Han Chinese population. Acta Derm Venereol. 2007; 87:335–340.
Article
19. Hernánz JM, Sánchez-Regaña M, Izu R, Mendiola V, García-Calvo C. Clinical and therapeutic evaluation of patients with moderate to severe psoriasis in Spain: the secuence study. Actas Dermosifiliogr. 2012; 103:897–904.
Article
20. Farber EM, Nall ML. The natural history of psoriasis in 5,600 patients. Dermatologica. 1974; 148:1–18.
Article
21. Hägg D, Eriksson M, Sundström A, Schmitt-Egenolf M. The higher proportion of men with psoriasis treated with biologics may be explained by more severe disease in men. PLoS One. 2013; 8:e63619.
Article
22. Fortes C, Mastroeni S, Leffondré K, Sampogna F, Melchi F, Mazzotti E, et al. Relationship between smoking and the clinical severity of psoriasis. Arch Dermatol. 2005; 141:1580–1584.
Article
23. Youn JI, Park BS, Park SB, Kim SD, Suh DH. Characterization of early and late onset psoriasis in the Korean population. J Dermatol. 1999; 26:647–652.
Article
24. Cohen AD, Weitzman D, Dreiher J. Psoriasis and hypertension: a case-control study. Acta Derm Venereol. 2010; 90:23–26.
Article
25. Chularojanamontri L, Kulthanan K, Suthipinittharm P, Jiamton S, Wongpraparut C, Silpa-Archa N, et al. Clinical differences between early- and late-onset psoriasis in Thai patients. Int J Dermatol. 2015; 54:290–294.
Article
26. Altobelli E, Petrocelli R, Marziliano C, Fargnoli MC, Maccarone M, Chimenti S, et al. Family history of psoriasis and age at disease onset in Italian patients with psoriasis. Br J Dermatol. 2007; 156:1400–1401.
Article
27. López-Estebaranz JL, Sánchez-Carazo JL, Sulleiro S. Effect of a family history of psoriasis and age on comorbidities and quality of life in patients with moderate to severe psoriasis: Results from the ARIZONA study. J Dermatol. 2016; 43:395–401.
Article
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