Korean J Dermatol.  2013 Jun;51(6):460-464.

Multiple Intradermal Soft Tissue Perineuriomas of the Digit

• Kim JH
• Choi JS
• Yun JH
• Kang HK
• Lee JR
• Roh JY
• Kim TE
• Ahn JS
• Baek JO

Abstract

Perineurioma is a rare benign peripheral nerve sheath tumor, composed uniformly of perineurial cells. Soft tissue perineurioma primarily arises within the subcutaneous tissue of extremities and trunk as a painless solitary nodule, and should be distinguished from dermatofibroma, neurofibroma, dermatofibrosarcoma protuberans, meningioma and so on. A 25 year-old female is presented with three small asymptomatic papules on the third left finger which were found 3 years ago. Punch biopsy was performed on all of the papules. Microscopic examination demonstrated well-demarcated tumor within dermis, and proliferation of spindle cells with wavy nuclei and elongated bipolar cytoplasmic process, arranged in a whorled pattern. According to immunohistochemical analysis, the tumor cell showed positivity for epithelial membrane antigen, but negativity for S-100 protein, factor XIIIa, CD34, and smooth muscle actin. The diagnosis of soft tissue perineurioma was being made. We report this rare case of perineurioma presented as multiple papules localized within dermis of the digit.

Keyword

Immunohistochemistry; Peripheral nerve sheath tumor; Soft tissue perineurioma

MeSH Terms

Actins
Biopsy
Cytoplasm
Dermatofibrosarcoma
Dermis
Extremities
Factor XIIIa
Female
Fingers
Histiocytoma, Benign Fibrous
Humans
Immunohistochemistry
Meningioma
Mucin-1
Muscle, Smooth
Nerve Sheath Neoplasms
Neurofibroma
Peripheral Nerves
S100 Proteins
Subcutaneous Tissue
Actins
Dermatofibrosarcoma
Factor XIIIa
Mucin-1
S100 Proteins