Exp Mol Med.
2017 Jul;49(7):e358. 10.1038/emm.2017.100.
Stimulation of osteoclast migration and bone resorption by C–C chemokine ligands 19 and 21
- Affiliations
-
- 1Department of Cell and Developmental Biology, BK21 Program and Dental Research Institute, Seoul National University, Seoul, Korea. hhbkim@snu.ac.kr
- 2Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea.
- 3Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea.
- KMID: 2388356
- DOI: http://doi.org/10.1038/emm.2017.100
Abstract
- Osteoclasts are responsible for the bone erosion associated with rheumatoid arthritis (RA). The upregulation of the chemokines CCL19 and CCL21 and their receptor CCR7 has been linked to RA pathogenesis. The purpose of this study was to evaluate the effects of CCL19 and CCL21 on osteoclasts and to reveal their underlying mechanisms. The expression of CCL19, CCL21 and CCR7 was higher in RA patients than in osteoarthritis patients. In differentiating osteoclasts, tumor necrosis factor-α, interleukin-1β and lipopolysaccharide stimulated CCR7 expression. CCL19 and CCL21 promoted osteoclast migration and resorption activity. These effects were dependent on the presence of CCR7 and abolished by the inhibition of the Rho signaling pathway. CCL19 and CCL21 promoted bone resorption by osteoclasts in an in vivo mice calvarial model. These findings demonstrate for the first time that CCL19, CCL21 and CCR7 play important roles in bone destruction by increasing osteoclast migration and resorption activity. This study also suggests that the interaction of CCL19 and CCL21 with CCR7 is an effective strategic focus in developing therapeutics for alleviating inflammatory bone destruction.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- NDRG2 Expression Decreases Tumor-Induced Osteoclast Differentiation by Down-regulating ICAM1 in Breast Cancer Cells
- Nuclear Factor-Kappa B Regulation of Osteoclastogenesis and Osteoblastogenesis
- Why to Keep Osteocytes Alive and How?
- Biological characteristics of osteoporosis drugs: the effect of osteoblast–osteoclast coupling
- Effect of Treponema lecithinolyticum lipopolysaccharide on matrix metalloproteinase-9 expression
