Ann Surg Treat Res.  2017 Jun;92(6):396-401. 10.4174/astr.2017.92.6.396.

Effectiveness of thymoquinone, zeolite, and platelet-rich plasma in model of corrosive oesophagitis induced in rats

• Karaca G
• Aydin O
• Pehlivanli F
• Altunkaya
• Uzun H
• Güler O

• KMID: 2387412
• DOI: http://doi.org/10.4174/astr.2017.92.6.396

Abstract

PURPOSE
The effectiveness of platelet-rich plasma (PRP), thymoquinone, and zeolite in corrosive esophageal burns was investigated in a rat model.
METHODS
Four groups were comprised as containing 10 rats in each group. For group I, oesophagitis was induced and no other procedure was performed (control group). For group II, oesophagitis was induced and thymoquinone was administered for 1 week via oral gavage once a day (thymoquinone group). For group III, oesophagitis was induced for 1 week via oral gavage once a day (PRP group). For group IV, oesophagitis was induced and zeolite was administered for 1 week via oral gavage once a day (zeolite group). On the 10th day, the rats were sacrificed under anaesthesia and venous blood sampling was performed from the vena portae. The oesophaguses were totally excised. Biochemically, interleukin (IL)-1B, IL-6, TNF-α, and MCP-1 were examined from venous blood. Inflammation score was evaluated histopathologically in oesophageal tissue that was collected.
RESULTS
There was a statistically significant difference among groups in terms of IL-1, IL-6, MCP levels, compared to the control group; median IL-1, IL-6, MCP levels of thymoquinone, PRP, and zeolite groups were statistically significantly lower. There was a statistically significant difference among groups in terms of inflammation scores, compared to group I; median inflammation scores of groups II, III and IV were statistically significantly lower thymoquinone.
CONCLUSION
PRP, and zeolite exhibited positive effect on recovery in oesophagitis by reducing inflammation in the involved segment.

Keyword

Thymoquinone; Platelet-rich plasma; Zeolite; Oesophagitis; Inflammation

MeSH Terms

Animals
Burns
Inflammation
Interleukin-1
Interleukin-6
Interleukins
Models, Animal
Platelet-Rich Plasma*
Rats*
Zeolites*
Interleukin-1
Interleukin-6
Interleukins
Zeolites

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