Ann Clin Neurophysiol.  2017 Jul;19(2):101-112. 10.14253/acn.2017.19.2.101.

How predictive are temporal lobe changes of underlying TDP-43 pathology in the ALS-FTD continuum?

Affiliations
  • 1Center of Mathematics, Computation and Cognition, Universidade Federal do ABC, Santo André, Brazil.
  • 2Department of Medicine, Norwich Medical School, University of East Anglia, Norwich, United Kingdom. m.hornberger@uea.ac.uk
  • 3Dementia and Complexity in Later Life, NHS Norfolk and Suffolk Foundation Trust, Norwich, United Kingdom.
  • 4Departament of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Abstract

Detection of underling proteinopathies is becoming increasingly important across neurodegenerative conditions due to upcoming disease intervention trials. In this review, we explored how temporal lobe changes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) can potentially predict underlying TDP-43 pathology subtypes in FTD. To date, emphasis has been given to frontal lobe changes in the study of the cognitive and behavioural impairments in both syndromes but an increasing number of pathological, imaging and neuropsychological studies suggest how temporal lobe changes could critically affect the cognition and behaviour of these conditions. In this current article, we reviewed pathological, imaging as well as clinical/neuropsychological findings of temporal involvement in the ALS-FTD continuum, how they relate to temporal lobe changes and the underlying TDP-43 pathology in FTD. Findings across studies show that TDP-43 pathology occurs and coincides in many structures in ALS and FTD, but especially in the temporal lobes. In particular, anterior and medial temporal lobes atrophy is consistently found in ALS and FTD. In addition, memory and language impairment as well as emotional and Theory of Mind processing deficits that are characteristics of the two diseases are highly correlated to temporal lobe dysfunction. We conclude by showing that temporal lobe changes due to TDP-43 type B might be particular predictive of TDP-43 type B pathology in behavioural variant FTD, which clearly needs to be investigated further in the future.

Keyword

Amyotrophic lateral sclerosis; Frontotemporal dementia; Memory; Temporal lobes

MeSH Terms

Amyotrophic Lateral Sclerosis
Atrophy
Cognition
Frontal Lobe
Frontotemporal Dementia
Memory
Pathology*
Temporal Lobe*
Theory of Mind

Reference

1.Kiernan AM., Vucic S., Cheah BC., Turner MR., Eisen A., Hardiman O, et al. Amyotrophic lateral sclerosis. Lancet. 2011. 377:942–955.
Article
2.Lam BY., Halliday GM., Irish M., Hodges JR., Piguet O. Longitudinal white matter changes in frontotemporal dementia subtypes. Human Brain Mapp. 2014. 35:3547–3557.
Article
3.Gorno-Tempini M., Dronkers NF., Rankin KP., Ogar JM., Phengrasamy L., Rosen HJ, et al. Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol. 2004. 55:335–346.
Article
4.Kirshner HS. Frontotemporal dementia and primary progressive aphasia, a review. Neuropsychiatr Dis Treat. 2014. 10:1045–1055.
Article
5.Ambikairajah A., Devenney E., Flanagan E., Yew B., Mioshi E., Kiernan MC, et al. A visual MRI atrophy rating scale for the amyotrophic lateral sclerosis-frontotemporal dementia continuum. Amyotroph Lateral Scler Frontotemporal Degener. 2014. 15:226–234.
Article
6.Lillo P., Mioshi E., Burrell JR., Kiernan MC., Hodges JR., Hornberger M. Grey and white matter changes across the amyotrophic lateral sclerosis-frontotemporal dementia continuum. PLoS One 2012:7:e43993.
7.Mezzapesa DM., Ceccarelli A., Dicuonzo F., Carella A., De Caro MF., Lopez M, et al. Whole-brain and regional brain atrophy in amyotrophic lateral sclerosis. AJNR Am J Neuroradiol. 2007. 28:255–259.
8.Nakano I. Frontotemporal dementia with motor neuron disease (amyotrophic lateral sclerosis with dementia). Neuropathology. 2000. 20:68–75.
Article
9.Tsermentseli S., Leigh PN., Goldstein LH. The anatomy of cognitive impairment in amyotrophic lateral sclerosis: more than frontal lobe dysfunction. Cortex. 2012. 48:166–182.
Article
10.Mackenzie IR., Rademakers R., Neumann M. TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia. Lancet Neurol. 2010. 9:995–1007.
Article
11.Li YQ., Tan MS., Yu JT., Tan L. Frontotemporal lobar degeneration: mechanisms and therapeutic strategies. Mol Neurobiol. 2016. 53:6091–6105.
Article
12.Saberi S., Stauffer JE., Schulte DJ., Ravits J. Neuropathology of amyotrophic lateral sclerosis and its variants. Neurol Clin. 2015. 33:855–876.
Article
13.Mackenzie IR., Rademakers R. The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia. Curr Opin in Neurol. 2008. 21:693–700.
Article
14.Fletcher PD., Warren JD. Semantic dementia: a specific net-work-opathy. J Mol Neurosci. 2011. 45:629–636.
Article
15.Anderson VE., Cairns NJ., Leigh PN. Involvement of the amygdala, dentate and hippocampus in motor neuron disease. J Neurol Sci. 1995. 129(Suppl):75–78.
Article
16.Geser F., Martinez-Lage M., Robinson J., Uryu K., Neumann M., Brand-meir NJ, et al. Clinical and pathological continuum of multisystem TDP-43 proteinopathies. Arch Neurol. 2009. 66:180–189.
Article
17.Behrouzi R., Liu X., Wu D., Robinson AC., Tanaguchi-Watanabe S., Rollinson S, et al. Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy. Acta Neuropathol Commun. 2016. 4:33.
Article
18.Mioshi E., Lillo P., Yew B., Hsieh S., Savage S., Hodges JR, et al. Cortical atrophy in ALS is critically associated with neuropsychiatric and cognitive changes. Neurology. 2013. 80:1117–1123.
Article
19.Zago S., Poletti B., Morelli C., Doretti A., Silani V. Amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). Arch Ital Biol. 2011. 149:39–56.
Article
20.Whitwell JL., Jack CR Jr., Parisi JE., Senjem ML., Knopman DS., Boeve BF, et al. Does TDP-43 type confer a distinct pattern of atrophy in frontotemporal lobar degeneration? Neurology. 2010. 75:2212–2220.
Article
21.Mackenzie IR., Neumann M., Baborie A., Sampathu DM., Du Plessis D., Jaros E, et al. A harmonized classification system for FTLD-TDP pathology. Acta Neuropathol. 2011. 122:111–113.
Article
22.Halliday GM., Kiernan MC., Kril JJ., Mito R., Masuda-Suzukake M., Hasegawa M, et al. TDP-43 in the hypoglossal nucleus identifies amyotrophic lateral sclerosis in behavioral variant frontotemporal dementia. J Neurol Sci. 2016. 366:197–201.
Article
23.Brettschneider J., Del Tredici K., Toledo JB., Robinson JL., Irwin DJ., Grossman M, et al. Stages of pTDP-43 pathology in amyotrophic lateral sclerosis. Ann Neurol. 2013. 74:20–38.
Article
24.Tan RH., Kril JJ., Fatima M., McGeachie A., McCann H., Shepherd C, et al. TDP-43 proteinopathies: pathological identification of brain regions differentiating clinical phenotypes. Brain. 2015. 138(Pt 10):3110–3122.
Article
25.Brettschneider J., Del Tredici K., Irwin DJ., Grossman M., Robinson JL., Toledo JB, et al. Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathol. 2014. 127:423–439.
Article
26.Rohrer JD. Behavioural variant frontotemporal dementia-defining genetic and pathological subtypes. J Mol Neurosci. 2011. 45:583–588.
Article
27.Fernández-Matarrubia M., Matías-Guiu JA., Moreno-Ramos T., Matí as-Guiu J. Biomarkers: a new approach to behavioural variant frontotemporal dementia. Neurologia. 2015. 30:50–61.
Article
28.Rohrer JD., Lashley T., Schott JM., Warren JE., Mead S., Isaacs AM, et al. Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration. Brain. 2011. 134(Pt 9):2565–2581.
29.Origone P., Accardo J., Verdiani S., Lamp M., Arnaldi D., Bellone E, et al. Neuroimaging features in C9orf72 and TARDBP double mutation with FTD phenotype. Neurocase. 2015. 21:529–534.
30.Cistaro A., Pagani M., Montuschi A., Calvo A., Moglia C., Canosa A, et al. The metabolic signature of C9ORF72-related ALS: FDG PET comparison with nonmutated patients. Eur J Nucl Med Mol Imaging. 2014. 41:844–852.
Article
31.Snowden JS., Rollinson S., Thompson JC., Harris JM., Stopford CL., Richardson AM, et al. Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations. Brain. 2012. 135(Pt 3):693–708.
Article
32.Whitwell JL., Weigand SD., Boeve BF., Senjem ML., Gunter JL., DeJe-sus-Hernandez M, et al. Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics. Brain. 2012. 135(Pt 3):794–806.
Article
33.Whitwell JL., Jack CR Jr., Senjem ML., Parisi JE., Boeve BF., Knopman DS, et al. MRI correlates of protein deposition and disease severity in postmortem frontotemporal lobar degeneration. Neurodege-ner Dis. 2009. 6:106–117.
Article
34.Kato S., Hayashi H., Yagishita A. Involvement of the frontotemporal lobe and limbic system in amyotrophic lateral sclerosis: as assessed by serial computed tomography and magnetic resonance imaging. J Neurol Sci. 1993. 116:52–58.
Article
35.Lindberg O., Östberg P., Zandbelt BB., Öberg J., Zhang Y., Andersen C, et al. Cortical morphometric subclassification of frontotemporal lobar degeneration. AJNR Am J Neuroradiol. 2009. 30:1233–1239.
Article
36.Knibb JA., Woollams AM., Hodges JR., Patterson K. Making sense of progressive nonfluent aphasia: an analysis of conversational speech. Brain 2009:132(Pt 10). 2734–2746.
Article
37.Rosen HJ., Gorno-Tempini ML., Goldman WP., Perry RJ., Schuff N., Weiner M, et al. Patterns of brain atrophy in frontotemporal dementia and semantic dementia. Neurology. 2002. 58:198–208.
Article
38.Ash S., Olm C., Mcmillan CT., Boller A., Irwin DJ., McCluskey L, et al. Deficits in sentence expression in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2015. 16:31–39.
Article
39.Cosottini M., Pesaresi I., Piazza S., Diciotti S., Cecchi P., Fabbri S, et al. Structural and functional evaluation of cortical motor areas in Amyotrophic Lateral Sclerosis. Exp Neurol. 2012. 234:169–180.
Article
40.Thivard L., Pradat PF., Lehéricy S., Lacomblez L., Dormont D., Chiras J, et al. Diffusion tensor imaging and voxel based morphometry study in amyotrophic lateral sclerosis: relationships with motor disability. J Neurol Neurosurg Psychiatry 2007:78. 889–892.
Article
41.Buhour MS., Doidy F., Laisney M., Pitel AL., de La Sayette V., Viader F, et al. Pathophysiology of the behavioral variant of frontotemporal lobar degeneration: a study combining MRI and FDG-PET. Brain Imaging Behav. 2017. 11:240–252.
Article
42.Moller C., Hafkemeijer A., Pijnenburg YA., Rombouts SA., van der Grond J., Dopper E, et al. Joint assessment of white matter integrity, cortical and subcortical atrophy to distinguish AD from behavioral variant FTD: a two-center study. NeuroImage Clin. 2015. 9:418–429.
Article
43.Irish M., Piguet O., Hodges JR., Hornberger M. Common and unique gray matter correlates of episodic memory dysfunction in frontotemporal dementia and alzheimer's disease. Human Brain Mapp. 2014. 35:1422–1435.
Article
44.Nguyen T., Bertoux M., O’Callaghan C., Ahmed S., Hodges J., Hornberger M. Grey and white matter brain network changes in frontotemporal dementia subtypes. Translat Neurosci. 2013. 4:410–418.
Article
45.de Souza LC., Chupin M., Bertoux M., Lehéricy S., Dubois B., Lamari F, et al. Is hippocampal volume a good marker to differentiate Alzheimer's disease from frontotemporal dementia? J Alzheimers Dis. 2013. 36:57–66.
Article
46.Hornberger M., Wong S., Tan R., Irish M., Piguet O., Kril J, et al. In vivo and postmortem memory circuit integrity in frontotemporal dementia and Alzheimer's disease. Brain. 2012. 135(Pt 10):3015–3025.
Article
47.Leslie FV., Hsieh S., Caga J., Savage SA., Mioshi E., Hornberger M, et al. Semantic deficits in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2015. 16:46–53.
Article
48.Ogar JM., Baldo JV., Wilson SM., Brambati SM., Miller BL., Dronkers NF, et al. Semantic dementia and persisting Wernicke's aphasia: linguistic and anatomical profiles. Brain Lang. 2011. 117:28–33.
Article
49.Mummery CJ., Patterson K., Price CJ., Ashburner J., Frackowiak RS., Hodges JR. A voxel-based morphometry study of semantic dementia: relationship between temporal lobe atrophy and semantic memory. Ann Neurol. 2000. 47:36–45.
Article
50.Rajagopalan V., Pioro EP. Comparing brain structural MRI and metabolic FDG-PET changes in patients with ALS-FTD: ‘the chicken or the egg?’ question. J Neurol Neurosurg Psychiatry. 2015. 86:953–958.
Article
51.Mori H., Yagishita A., Takeda T., Mizutani T. Symmetric temporal abnormalities on MR imaging in amyotrophic lateral sclerosis with dementia. AJNR Am J Neuroradiol. 2007. 28:1511–1516.
Article
52.Christidi F., Zalonis I., Kyriazi S., Rentzos M., Karavasilis E., Wilde EA, et al. Uncinate fasciculus microstructure and verbal episodic memory in amyotrophic lateral sclerosis: a diffusion tensor imaging and neuropsychological study. Brain Imaging Behav. 2014. 8:497–505.
Article
53.Canu E., Agosta F., Riva N., Sala S., Prelle A., Caputo D, et al. The to-pography of brain microstructural damage in amyotrophic lateral sclerosis assessed using diffusion tensor MR imaging. AJNR Am J Neuroradiol. 2011. 32:1307–1314.
Article
54.Sarro L., Agosta F., Canu E., Riva N., Prelle A., Copetti M, et al. Cognitive functions and white matter tract damage in amyotrophic lateral sclerosis: a diffusion tensor tractography study. AJNR Am J Neuroradiol. 2011. 32:1866–1872.
Article
55.Mahoney CJ., Ridgway GR., Malone IB., Downey LE., Beck J., Kin-nunen KM, et al. Profiles of white matter tract pathology in frontotemporal dementia. Human Brain Mapp. 2014. 35:4163–4179.
Article
56.Whitwell JL., Avula R., Senjem ML., Kantarci K., Weigand SD., Samiko-glu A, et al. Gray and white matter water diffusion in the syndrom-ic variants of frontotemporal dementia. Neurology. 2010. 74:1279–1287.
Article
57.Galantucci S., Tartaglia MC., Wilson SM., Henry ML., Filippi M., Agosta F, et al. White matter damage in primary progressive aphasias: a diffusion tensor tractography study. Brain. 2011. 134(Pt 10):3011–3029.
Article
58.Pagani M., Chiò A., Valentini MC., Öberg J., Nobili F., Calvo A, et al. Functional pattern of brain FDG-PET in amyotrophic lateral sclerosis. Neurology. 2014. 83:1067–1074.
Article
59.Garraux G., Salmon E., Degueldre C., Lemaire C., Franck G. Medial temporal lobe metabolic impairment in dementia associated with motor neuron disease. J Neurol Sci. 1999. 168:145–150.
Article
60.Cerami C., Dodich A., Iannaccone S., Marcone A., Lettieri G., Crespi C, et al. Right limbic FDG-PET hypometabolism correlates with emotion recognition and attribution in probable behavioral variant of frontotemporal dementia patients. PLoS One. 2015. 10:e0141672.
Article
61.Mion M., Patterson K., Acosta-Cabronero J., Pengas G., Izquierdo-Gar-cia D., Hong YT, et al. What the left and right anterior fusiform gyri tell us about semantic memory. Brain. 2010. 133:3256–3268.
Article
62.Desgranges B., Matuszewski V., Piolino P., Chételat G., Mézenge F., Landeau B, et al. Anatomical and functional alterations in semantic dementia: a voxel-based MRI and PET study. Neurobiol Aging. 2007. 28:1904–1913.
Article
63.Diehl J., Grimmer T., Drzezga A., Riemenschneider M., Förstl H., Kurz A. Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia. A PET study. Neurobiol Aging. 2004. 25:1051–1056.
Article
64.Klüver H., Bucy PC. Preliminary analysis of functions of the temporal lobes in monkeys. 1939. J Neuropsychiatry Clin Neurosci. 1997. 9:606–620.
Article
65.Lilly R., Cummings JL., Benson DF., Frankel M. The human Klü ver-Bu-cy syndrome. Neurology. 1983. 33:1141–1145.
Article
66.Mendez MF., Perryman KM. Neuropsychiatric features of frontotemporal dementia: evaluation of consensus criteria and review. J Neuropsychiatry Clin Neurosci. 2002. 14:424–429.
Article
67.Tang-Wai D., Lewis P., Boeve B., Hutton M., Golde T., Baker M, et al. Familial frontotemporal dementia associated with a novel preseni-lin-1 mutation. Dement Geriatr Cogn Disord. 2002. 14:13–21.
Article
68.Rascovsky K., Hodges JR., Knopman D., Mendez MF., Kramer JH., Neuhaus J, et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011. 134(Pt 9):2456–2477.
Article
69.Perry RJ., Graham A., Williams G., Rosen H., Erzinç lioglu S., Weiner M, et al. Patterns of frontal lobe atrophy in frontotemporal dementia: a volumetric MRI study. Dement Geriatr Cogn Disord. 2006. 22:278–287.
Article
70.Dickson DW., Horoupian DS., Thal LJ., Davies P., Walkley S., Terry RD. Klüver‐ Bucy syndrome and amyotrophic lateral sclerosis: a case report with biochemistry, morphometrics, and Golgi study. Neurology. 1986. 36:1323–1329.
Article
71.Bertoux M., Volle E., Funkiewiez A., de Souza LC., Leclercq D., Dubois B. Social Cognition and Emotional Assessment (SEA) is a marker of medial and orbital frontal functions: a voxel-based morphometry study in behavioral variant of frontotemporal degeneration. J Int Neuropsychol Soc. 2012. 18:972–985.
Article
72.Bertoux M., de Souza LC., Corlier F., Lamari F., Bottlaender M., Dubois B, et al. Two distinct amnesic profiles in behavioral variant frontotemporal dementia. Biol Psychiatry. 2014. 75:582–588.
Article
73.van der Hulst EJ., Bak TH., Abrahams S. Impaired affective and cognitive theory of mind and behavioural change in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2015. 86:1208–1215.
Article
74.Henry JD., Phillips LH., von Hippel C. A meta-analytic review of theory of mind difficulties in behavioural-variant frontotemporal dementia. Neuropsychologia. 2014. 56:53–62.
Article
75.Zahn R., Moll J., Iyengar V., Huey ED., Tierney M., Krueger F, et al. Social conceptual impairments in frontotemporal lobar degeneration with right anterior temporal hypometabolism. Brain. 2009. 132(Pt 3):604–616.
Article
76.Moll J., Zahn R., de Oliveira-Souza R., Krueger F., Grafman J. Opinion: the neural basis of human moral cognition. Nat Rev Neurosci. 2005. 6:799–809.
Article
77.Olson IR., Plotzker A., Ezzyat Y. The Enigmatic temporal pole: a review of findings on social and emotional processing. Brain. 2007. 130(Pt 7):1718–1731.
Article
78.Bejanin A., Chételat G., Laisney M., Pélerin A., Landeau B., Merck C, et al. Distinct neural substrates of affective and cognitive theory of mind impairment in semantic dementia. Soc Neurosci. 2017. 12:287–302.
Article
79.Duval C., Bejanin A., Piolino P., Laisney M., de La Sayette V., Belliard S, et al. Theory of mind impairments in patients with semantic dementia. Brain. 2012. 135(Pt 1):228–241.
Article
80.Irish M., Hodges JR., Piguet O. Right anterior temporal lobe dysfunction underlies theory of mind impairments in semantic dementia. Brain. 2014. 137(Pt 4):1241–1253.
Article
81.Consonni M., Rossi S., Cerami C., Marcone A., Iannaccone S., Frances-co Cappa S, et al. Executive dysfunction affects word list recall performance: evidence from amyotrophic lateral sclerosis and other neurodegenerative diseases. J Neuropsychol. 2017. 11:74–90.
Article
82.Raaphorst J., van Tol MJ., de Visser M., van der Kooi AJ., Majoie CB., van den Berg LH, et al. Prose memory impairment in amyotrophic lateral sclerosis patients is related to hippocampus volume. Eur J Neurol. 2015. 22:547–554.
Article
83.Abdulla S., Machts J., Kaufmann J., Patrick K., Kollewe K., Dengler R, et al. Hippocampal degeneration in patients with amyotrophic lateral sclerosis. Neurobiol Aging. 2014. 35:2639–2645.
Article
84.Kasper E., Schuster C., Machts J., Kaufmann J., Bittner D., Vielhaber S, et al. Microstructural white matter changes underlying cognitive and behavioural impairment in ALS - an in vivo study using DTI. PLoS One. 2014. 9:e114543.
Article
85.Barbagallo G., Nicoletti G., Cherubini A., Trotta M., Tallarico T., Chiriaco C, et al. Diffusion tensor MRI changes in gray structures of the frontal-subcortical circuits in amyotrophic lateral sclerosis. Neurol Sci. 2014. 35:911–918.
Article
86.Davies RR., Halliday GM., Xuereb JH., Kril JJ., Hodges JR. The neural basis of semantic memory: evidence from semantic dementia. Neurobiol Aging. 2009. 30:2043–2052.
Article
87.Stoppel CM., Vielhaber S., Eckart C., Machts J., Kaufmann J., Heinze HJ, et al. Structural and functional hallmarks of amyotrophic lateral sclerosis progression in motor -and memory- related brain regions. Neuroimage Clin. 2014. 5:277–290.
Article
88.Takeda T., Uchihara T., Arai N., Mizutani T., Iwata M. Progression of hippocampal degeneration in amyotrophic lateral sclerosis with or without memory impairment: distinction from Alzheimer disease. Acta Neuropathol. 2009. 117:35–44.
Article
89.Meoded A., Kwan JY., Peters TL., Huey ED., Danielian LE., Wiggs E, et al. Imaging findings associated with cognitive performance in primary lateral sclerosis and amyotrophic lateral sclerosis. Dement Geriatr Cogn Dis Extra. 2013. 3:233–250.
Article
90.Taylor LJ., Brown RG., Tsermentseli S., Al-Chalabi A., Shaw CE., Ellis C, et al. Is language impairment more common than executive dysfunction in amyotrophic lateral sclerosis? J Neurol Neurosurg Psychiatry. 2013. 84:494–498.
Article
91.McKinnon MC., Nica EI., Sengdy P., Kovacevic N., Moscovitch M., Freedman M, et al. Autobiographical memory and patterns of brain atrophy in frontotemporal lobar degeneration. J Cogn Neurosci. 2008. 20:1839–1853.
Article
92.Abrahams S., Goldstein LH., Suckling J., Ng V., Simmons A., Chitnis X, et al. Frontotemporal white matter changes in amyotrophic lateral sclerosis. J Neurol. 2005. 252:321–331.
Article
93.Papps B., Abrahams S., Wicks P., Leigh PN., Goldstein LH. Changes in memory for emotional material in amyotrophic lateral sclerosis (ALS). Neuropsychologia. 2005. 43:1107–1114.
Article
94.Achi EY., Rudnicki SA. ALS and frontotemporal dysfunction: a review. Neurol Res Int. 2012. 2012:806306.
Article
95.Hornberger M., Piguet O., Graham AJ., Nestor PJ., Hodges JR. How preserved is episodic memory in behavioral variant frontotemporal dementia? Neurology. 2010. 74:472–479.
Article
96.Bertoux M., O’Callaghan C., Dubois B., Hornberger M. In two minds: executive functioning versus theory of mind in behavioural variant frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2016. 87:231–234.
97.Hornberger M., Piguet O. Episodic memory in frontotemporal dementia: a critical review. Brain. 2012. 135(Pt 3):678–692.
98.Mantovan MC., Baggio L., Dalla Barba G., Smith P., Pegoraro E., Soraru’ G, et al. Memory deficits and retrieval processes in ALS. Eur J Neurol. 2003. 10:221–227.
Article
99.Goldstein LH., Abrahams S. Changes in cognition and behaviour in amyotrophic lateral sclerosis: nature of impairment and implications for assessment. Lancet Neurol. 2013. 12:368–380.
Article
100.Christidi F., Karavasilis E., Zalonis I., Ferentinos P., Giavri Z., Wilde EA, et al. Memory-related white matter tract integrity in amyotrophic lateral sclerosis: an advanced neuroimaging and neuropsychological study. Neurobiol Aging. 2017. 49:69–78.
Article
101.Machts J., Bittner V., Kasper E., Schuster C., Prudlo J., Abdulla S, et al. Memory deficits in amyotrophic lateral sclerosis are not exclusively caused by executive dysfunction: a comparative neuropsychological study of amnestic mild cognitive impairment. BMC Neruosci. 2014. 15:83.
Article
102.Phukan J., Elamin M., Bede P., Jordan N., Gallagher L., Byrne S, et al. The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study. J Neurol Neurosurg Psychiatry. 2012. 83:102–108.
Article
103.Consonni M., Catricalà E., Dalla Bella E., Gessa VC., Lauria G., Cappa SF. Beyond the consensus criteria: multiple cognitive profiles in amyotrophic lateral sclerosis? Cortex. 2016. 81:162–167.
Article
104.Hodges JR., Patterson K. Semantic dementia: a unique clinicopath-ological syndrome. Lancet Neurol. 2007. 6:1004–1014.
Article
105.Libon DJ., McMillan C., Avants B., Boller A., Morgan B., Burkholder L, et al. Deficits in concept formation in amyotrophic lateral sclerosis. Neuropsychology. 2012. 26:422–429.
Article
106.Kanda T., Ishii K., Uemura T., Miyamoto N., Yoshikawa T., Kono AK, et al. Comparison of grey matter and metabolic reductions in frontotemporal dementia using FDG-PET and voxel-based morphomet-ric MR studies. Eur J Nucl Med Mol Imaging. 2008. 35:2227–2234.
Article
107.Abrahams S., Goldstein LH., Simmons A., Brammer M., Williams SC., Giampietro V, et al. Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain. 2004. 127(Pt 7):1507–1517.
Article
108.Ash S., Menaged A., Olm C., McMillan CT., Boller A., Irwin DJ, et al. Narrative discourse deficits in amyotrophic lateral sclerosis. Neurology. 2014. 83:520–528.
Article
109.Hardy CJ., Buckley AH., Downey LE., Lehmann M., Zimmerer VC., Varley RA, et al. The language profile of behavioral variant frontotemporal dementia. J Alzheimers Dis. 2016. 50:359–371.
Article
110.Borroni B., Grassi M., Premi E., Gazzina S., Alberici A., Cosseddu M, et al. Neuroanatomical correlates of behavioural phenotypes in behavioural variant of frontotemporal dementia. Behav Brain Res. 2012. 235:124–129.
Article
111.McMillan C., Gee J., Moore P., Dennis K., DeVita C., Grossman M. Confrontation naming and morphometric analyses of structural MRI in frontotemporal dementia. Dement Geriatr Cogn Disord. 2004. 17:320–323.
Article
112.Hsieh S., Hornberger M., Piguet O., Hodges JR. Brain correlates of musical and facial emotion recognition: evidence from the dementias. Neuropsychologia. 2012. 50:1814–1822.
Article
113.Crespi C., Cerami C., Dodich A., Canessa N., Arpone M., Iannaccone S, et al. Microstructural white matter correlates of emotion recognition impairment in Amyotrophic Lateral Sclerosis. Cortex. 2014. 53:1–8.
Article
114.Oh SI., Oh KW., Kim HJ., Park JS., Kim SH. Impaired perception of emotional expression in amyotrophic lateral sclerosis. J Clin Neurol. 2016. 12:295–300.
Article
115.Zimmerman EK., Eslinger PJ., Simmons Z., Barrett AM. Emotional perception deficits in amyotrophic lateral sclerosis. Cogn Behav Neurol. 2007. 20:79–82.
Article
116.Kumfor F., Hutchings R., Irish M., Hodges JR., Rhodes G., Palermo R, et al. Do I know you? Examining face and object memory in frontotemporal dementia. Neuropsychologia. 2015. 71:101–111.
Article
117.Goodkind MS., Sturm VE., Ascher EA., Shdo SM., Miller BL., Rankin KP, et al. Emotion recognition in frontotemporal dementia and Alzheimer's disease: a new film-based assessment. Emotion. 2015. 15:416–427.
Article
118.Kumfor F., Miller L., Lah S., Hsieh S., Savage S., Hodges JR, et al. Are you really angry? The effect of intensity on facial emotion recognition in frontotemporal dementia. Soc Neurosci. 2011. 6:502–514.
Article
119.Bickart KC., Dickerson BC., Barrett LF. The amygdala as a hub in brain networks that support social life. Neuropsychologia. 2014. 63:235–248.
Article
120.Canli T., Zhao Z., Brewer J., Gabrieli JD., Cahill L. Event-related acti-vation in the human amygdala associates with later memory for individual emotional experience. J Neurosci. 2000. 20:RC99.
Article
121.Kumfor F., Piguet O. Disturbance of emotion processing in frontotemporal dementia: a synthesis of cognitive and neuroimaging findings. Neuropsychol Rev. 2012. 22:280–297.
Article
122.Hamann S. Cognitive and neural mechanisms of emotional memory. Trends Cogn Sci. 2001. 5:394–400.
Article
123.Kamminga J., Kumfor F., Burrell JR., Piguet O., Hodges JR., Irish M. Differentiating between right-lateralised semantic dementia and behavioural-variant frontotemporal dementia: an examination of clinical characteristics and emotion processing. J Neurol Neurosurg Psychiatry. 2015. 86:1082–1088.
Article
124.Markowitsch HJ., Staniloiu A. Amygdala in action: relaying biolog-ical and social significance to autobiographical memory. Neuropsychologia. 2011. 49:718–733.
Article
125.Staios M., Fisher F., Lindell AK., Ong B., Howe J., Reardon K. Exploring sarcasm detection in amyotrophic lateral sclerosis using ecologi-cally valid measures. Front Hum Neurosci. 2013. 7:178.
Article
126.Kipps CM., Nestor PJ., Acosta-Cabronero J., Arnold R., Hodges JR. Understanding social dysfunction in the behavioural variant of frontotemporal dementia: the role of emotion and sarcasm processing. Brain. 2009. 132(Pt 3):592–603.
Article
127.Rajagopalan V., Pioro EP. Distinct patterns of cortical atrophy in ALS patients with or without dementia: an MRI VBM study. Amyotroph Lateral Scler Frontotemporal Degener. 2014. 15:216–225.
Article
128.Walterfang M., Luders E., Looi JC., Rajagopalan P., Velakoulis D., Thompson PM, et al. Shape analysis of the corpus callosum in Alzheimer's disease and frontotemporal lobar degeneration subtypes. J Alzheimers Dis. 2014. 40:897–906.
Article
129.Agosta F., Scola E., Canu E., Marcone A., Magnani G., Sarro L, et al. White matter damage in frontotemporal lobar degeneration spectrum. Cereb Cortex. 2012. 22:2705–2714.
Article
130.Whitwell JL., Sampson EL., Watt HC., Harvey RJ., Rossor MN., Fox NC. A volumetric magnetic resonance imaging study of the amygdala in frontotemporal lobar degeneration and Alzheimer's disease. Dement Geriatr Cogn Disord. 2005. 20:238–244.
Article
131.Pinkhardt EH., van Elst LT., Ludolph AC., Kassubek J. Amygdala size in amyotrophic lateral sclerosis without dementia: an in vivo study using MRI volumetry. BMC Neurol. 2006. 6:48.
Article
132.Abrahams S., Goldstein LH., Kew JJ., Brooks DJ., Lloyd CM., Frith CD, et al. Frontal lobe dysfunction in amyotrophic lateral sclerosis. A PET study. Brain. 1996. 119(Pt 6):2105–2120.
Article
133.Moon WJ., Kim HJ., Roh HG., Han SH. Atrophy measurement of the anterior commissure and substantia innominata with 3T high-resolution MR imaging: does the measurement differ for patients with frontotemporal lobar degeneration and Alzheimer disease and for healthy subjects? AJNR Am J Neuroradiology. 2008. 29:1308–1313.
Article
134.Schuster C., Kasper E., Machts J., Bittner D., Kaufmann J., Benecke R, et al. Longitudinal course of cortical thickness decline in amyotrophic lateral sclerosis. J Neurol. 2014. 261:1871–1880.
Article
135.Schuster C., Kasper E., Dyrba M., Machts J., Bittner D., Kaufmann J, et al. Cortical thinning and its relation to cognition in amyotrophic lateral sclerosis. Neurobiol Aging. 2014. 35:240–246.
Article
136.Lu PH., Mendez MF., Lee GJ., Leow AD., Lee HW., Shapira J, et al. Patterns of brain atrophy in clinical variants of frontotemporal lobar degeneration. Dement Geria Cogn Disord. 2013. 35:34–50.
Article
137.Peelle JE., Troiani V., Gee J., Moore P., McMillan C., Vesely L, et al. Sentence comprehension and voxel-based morphometry in progressive nonfluent aphasia, semantic dementia, and nonaphasic frontotemporal dementia. J Neurolinguistics. 2008. 21:418–432.
Article
138.Whitwell JL., Jack CR Jr., Parisi JE., Knopman DS., Boeve BF., Petersen RC, et al. Imaging signatures of molecular pathology in behavioral variant frontotemporal dementia. J Mol Neurosci. 2011. 45:372–378.
Article
139.Whitwell JL., Boeve BF., Weigand SD., Senjem ML., Gunter JL., Baker MC, et al. Brain atrophy over time in genetic and sporadic frontotemporal dementia: a study of 198 serial magnetic resonance images. Eur J Neurol. 2015. 22:745–752.
Article
140.Zhang Y., Tartaglia MC., Schuff N., Chiang GC., Ching C., Rosen HJ, et al. MRI signatures of brain macrostructural atrophy and microstructural degradation in frontotemporal lobar degeneration subtypes. J Alzheimers Dis. 2013. 33:431–444.
141.Hornberger M., Geng J., Hodges JR. Convergent grey and white matter evidence of orbitofrontal cortex changes related to disinhibition in behavioural variant frontotemporal dementia. Brain. 2011. 134(Pt 9):2502–2512.
142.Steketee RM., Meijboom R., de Groot M., Bron EE., Niessen WJ., van der Lugt A, et al. Concurrent white and gray matter degeneration of disease-specific networks in early-stage Alzheimer's disease and behavioral variant frontotemporal dementia. Neurobiol Aging. 2016. 43:119–128.
Article
143.Wong S., Flanagan E., Savage G., Hodges JR., Hornberger M. Contrasting prefrontal cortex contributions to episodic memory dysfunction in behavioural variant frontotemporal dementia and Alzheimer's disease. PloS One. 2014. 9:e87778.
Article
144.Whitwell JL., Jack CR Jr., Senjem ML., Josephs KA. Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration. Neurology. 2006. 66:102–104.
145.Coon EA., Whitwell JL., Parisi JE., Dickson DW., Josephs KA. Right temporal variant frontotemporal dementia with motor neuron disease. J Clin Neurosci. 2012. 19:85–91.
146.Le Ber I., Camuzat A., Hannequin D., Pasquier F., Guedj E., Rovelet-Lec-rux A, et al. Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study. Brain. 2008. 131(Pt 3):732–746.
Article
147.Rohrer JD., Warren JD., Modat M., Ridgway GR., Douiri A., Rossor MN, et al. Patterns of cortical thinning in the language variants of frontotemporal lobar degeneration. Neurology. 2009. 72:1562–1569.
Article
148.Acosta-Cabronero J., Patterson K., Fryer TD., Hodges JR., Pengas G., Williams GB, et al. Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story. Brain. 2011. 134(Pt 4):2025–2035.
Article
149.Downey LE., Mahoney CJ., Buckley AH., Golden HL., Henley SM., Schmitz N, et al. White matter tract signatures of impaired social cognition in frontotemporal lobar degeneration. Neuroimage Clin. 2015. 8:640–651.
Article
150.Irish M., Devenney E., Wong S., Dobson-Stone C., Kwok JB., Piguet O, et al. Neural substrates of episodic memory dysfunction in behavioural variant frontotemporal dementia with and without C9ORF72 expansions. Neuroimage Clin. 2013. 2:836–843.
Article
151.Viard A., Piolino P., Belliard S., de La Sayette V., Desgranges B., Eu-stache F. Episodic future thinking in semantic dementia: a cognitive and FMRI study. PloS One. 2014. 9:e111046.
Article
152.Chan D., Fox NC., Scahill RI., Crum WR., Whitwell JL., Leschziner G, et al. Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease. Ann Neurol. 2001. 49:433–442.
Article
153.Lagarde J., Valabrè gue R., Corvol JC., Pineau F., Le Ber I., Vidailhet M, et al. Are frontal cognitive and atrophy patterns different in PSP and bvFTD? A comparative neuropsychological and VBM study. PloS One. 2013. 8:e80353.
Article
154.Hornberger M., Yew B., Gilardoni S., Mioshi E., Gleichgerrcht E., Manes F, et al. Ventromedial‐ frontopolar prefrontal cortex atrophy correlates with insight loss in frontotemporal dementia and Alzheimer's disease. Hum Brain Mapp. 2014. 35:616–626.
Article
155.Irish M., Eyre N., Dermody N., O’Callaghan C., Hodges JR., Hornberger M, et al. Neural substrates of semantic prospection - evidence from the Dementias. Front Behav Neurosci. 2016. 10:96.
Article
156.Matías-Guiu JA., Pytel V., Cabrera-Martín MN., Galán L., Valles-Salgado M., Guerrero A, et al. Amyloid-and FDG-PET imaging in amyotrophic lateral sclerosis. Eur J Nucl Med Mol Imaging. 2016. 43:2050–2060.
Article
157.Maani R., Yang YH., Emery D., Kalra S. Cerebral degeneration in amyotrophic lateral sclerosis revealed by 3-dimensional texture analysis. Front Neurosci. 2016. 10:120.
Article
158.Morbelli S., Ferrara M., Fiz F., Dessi B., Arnaldi D., Picco A, et al. Map-ping brain morphological and functional conversion patterns in predementia late-onset bvFTD. Eur J Nucl Med Mol Imaging. 2016. 43:1337–1347.
Article
159.Evans J., Olm C., McCluskey L., Elman L., Boller A., Moran E, et al. Impaired cognitive flexibility in amyotrophic lateral sclerosis. Cogn Behav Neurol. 2015. 28:17–26.
Article
160.Massimo L., Powers JP., Evans LK., McMillan CT., Rascovsky K., Eslinger P, et al. Apathy in frontotemporal degeneration: Neuroanatomical evidence of impaired goal-directed behavior. Front Hum Neurosci. 2015. 9:611.
Article
161.Tovar-Moll F., de Oliveira-Souza R., Bramati IE., Zahn R., Cavanagh A., Tierney M, et al. White matter tract damage in the behavioral variant of frontotemporal and corticobasal dementia syndromes. PloS One. 2014. 9:e102656.
Article
162.Zhang Y., Schuff N., Du AT., Rosen HJ., Kramer JH., Gorno-Tempini ML, et al. White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI. Brain. 2009. 132(Pt 9):2579–2592.
Article
163.Zhang J., Yin X., Zhao L., Evans AC., Song L., Xie B, et al. Regional alterations in cortical thickness and white matter integrity in amyotrophic lateral sclerosis. J Neurol. 2014. 261:412–421.
Article
164.Powers JP., Massimo L., McMillan CT., Yushkevich PA., Zhang H., Gee JC, et al. White matter disease contributes to apathy and disinhibition in behavioral variant frontotemporal dementia. Cogn Behav Neurol. 2014. 27:206–214.
Article
165.Hartung V., Prell T., Gaser C., Turner MR., Tietz F., Ilse B, et al. Vox-el-based MRI intensitometry reveals extent of cerebral white matter pathology in amyotrophic lateral sclerosis. PloS One. 2014. 9:e104894.
Article
166.Filippini N., Douaud G., Mackay CE., Knight S., Talbot K., Turner MR. Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis. Neurology. 2010. 75:1645–1652.
167.Kassubek J., Unrath A., Huppertz HJ., Lulé D., Ethofer T., Sperfeld AD, et al. Global brain atrophy and corticospinal tract alterations in ALS, as investigated by voxel‐ based morphometry of 3‐ D MRI. Amyotrophic Lateral SclerosisAmyotroph Lateral Scler Other Motor Neuron Disord. 2005. 6:213–220.
Full Text Links
  • ACN
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr