Psychiatry Investig.  2017 Jul;14(4):499-505. 10.4306/pi.2017.14.4.499.

Transdermal Nicotine Patch Effects on EEG Power Spectra and Heart Rate Variability During Sleep of Healthy Male Adults

• Choi JB
• Lee YJ
• Jeong DU

• KMID: 2387142
• DOI: http://doi.org/10.4306/pi.2017.14.4.499

Abstract

OBJECTIVE
The effect of transdermal nicotine patch on sleep physiology is not well established. The current study aimed to examine the influence of nicotine patch on homeostatic sleep propensity and autonomic nervous system.
METHODS
We studied 16 non-smoking young healthy volunteers with nocturnal polysomnography in a double blind crossover design between sleep with and without nicotine patch. We compared the sleep variables, sleep EEG power spectra, and heart rate variability.
RESULTS
The night with nicotine patch showed significant increase in sleep latency, wake after sleep onset, and stage 1 sleep; and decrease in total sleep time, sleep efficiency, and percentage of REM sleep. Also, spectral analysis of the sleep EEG in the night with nicotine patch revealed decreased slow wave activity in stage 2 and REM sleep and increased alpha activity in the first NREM-REM sleep cycle. Heart rate variability showed no differences between the 2 nights, but the low to high ratio (a parameter indicative of sympathetic nervous system activity) positively correlated with wake after sleep onset in night with nicotine patch.
CONCLUSION
Transdermal nicotine patch significantly disrupts sleep continuity, sleep architecture, and homeostatic sleep propensity. The overactivation of the sympathetic nervous system may be responsible for these changes.

Keyword

Nicotine; Sleep; Polysomnography; Spectrum analysis; Heart rate variability

MeSH Terms

Adult*
Autonomic Nervous System
Cross-Over Studies
Electroencephalography*
Healthy Volunteers
Heart Rate*
Heart*
Humans
Male*
Nicotine*
Physiology
Polysomnography
Sleep, REM
Spectrum Analysis
Sympathetic Nervous System
Tobacco Use Cessation Products*
Nicotine