Nat Prod Sci.  2017 Jun;23(2):113-118. 10.20307/nps.2017.23.2.113.

Integracide K: A New Tetracyclic Triterpenoid from Desmodium uncinatum (Jacq.) DC. (Fabaceae)

• Tsafack BT
• Ponou BK
• Teponno RB
• Nono RN
• Jenett-Siems K
• Melzig MF
• Park HJ
• Tapondjou

• KMID: 2387061
• DOI: http://doi.org/10.20307/nps.2017.23.2.113

Abstract

A new tetracyclic triterpenoid [4,4,24-trimethylcholesta-Δ(8,9;14,15;24,28)-trien-3β,11β,12α-triol-12-acetate, 3-sulfate] sodium salt (1), together with eight known compounds including ergosterol 5α,8α-endoperoxide (2), 1,9-dihydroxy-3-methoxy-2-methylpterocarpan (3), 3-O-β-D-2-acetyl-amino-2-deoxyglucopyranoxyloleanoic acid (4), hydnocarpin (5), derrone (6), isovitexin (7), erythrinin C (8), and 5,4'-dihydroxy-2''-hydroxyisopropyldihydrofurano [4,5:7,8]-isoflavone (9), were isolated from the EtOAc soluble fraction of the methanol extract of aerial part of Desmodium uncinatum collected in the western highland of Cameroon. The structures of these compounds were established by comprehensive interpretation of their spectral data mainly including 1D- (¹H and ¹³C), 2D-NMR (¹H-¹H COSY, HMQC, HMBC) spectroscopic and ESI-TOF-MS mass spectrometric analysis. The isolation of an integracide-like compound from plant origin is a very unusual finding.

Keyword

Desmodium uncinatum; Fabaceae; Tetracyclic triterpenoid; Integracide; Isoflavonoids

MeSH Terms

Cameroon
Ergosterol
Fabaceae
Methanol
Plants
Sodium
Ergosterol
Methanol
Sodium

Figure

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  Fig. 1. Chemical structures of compounds isolated from Desmodium uncinatum.

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  Fig. 2. Selected HMBC correlations of Integracide K (1).

Reference

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