Korean J Vet Res.
2017 Jun;57(2):105-111. 10.14405/kjvr.2017.57.2.105.
Comparative in vivo biodistributions of nanoparticles and polymers of ¹â·â·lutetium-labeled hyaluronic acids in mice during 28 days
- Affiliations
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- 1College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
- 2College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University, Cheongju 28644, Korea. synam@cbu.ac.kr
- 3Division of Biosafety Evaluation and Control, Centers for Disease Control & Prevention, Cheongju 28159, Korea.
- 4Asan Institute for Life Sciences, Asan Medical Center and University of Ulsan, Seoul 05505, Korea.
- 5College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.
- KMID: 2386851
- DOI: http://doi.org/10.14405/kjvr.2017.57.2.105
Abstract
- Hyaluronic acid (HA) has been investigated for biomedical and pharmaceutical applications. This study was conducted to determine the distributions of HA nanoparticles (NPs; size 350-400 nm) and larger HA polymers in mice at intervals after application. ¹â·â·Lutetium (Lu)-labeled HA-NPs or HA polymers were intravenously injected (5 mg/kg) into male ICR mice, and radioactivity levels in blood and target organs were measured from 0.25 h to 28 days post-injection. In blood, the radioactivities of HA-NPs and HA polymer peaked at 0.5 h after injection but were remarkably decreased at 2 h; subsequently, they maintained a constant level until 6 days post-injection. HA-NPs and HA polymers were observed in the liver, spleen, lung, kidney, and heart (in ascending order) but were seldom observed in other organs. After 3 days, both the HA-NP and HA polymer levels showed similar steady decreases in lung, kidney, and heart. However, in liver and spleen, the HA-NP levels tended to decrease gradually after 1 day and both were very low after 14 days, whereas the HA polymer level accumulated for 28 days. The results indicate that HA-NPs, with their faster clearance pattern, may act as a better drug delivery system than HA polymers, especially in the liver and spleen.
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