J Korean Med Assoc.  2017 Jul;60(7):561-567. 10.5124/jkma.2017.60.7.561.

Diagnosis of liver cirrhosis

• Seo YS

• KMID: 2386597
• DOI: http://doi.org/10.5124/jkma.2017.60.7.561

Abstract

Liver cirrhosis results from chronic liver injury that leads to necroinflammation and fibrosis. The development of liver cirrhosis is significantly associated with increased morbidity and mortality. Liver biopsy has been considered to be the gold standard for the diagnosis of liver cirrhosis, which is characterized by diffuse fibrosis and the development of regenerating nodules. However, liver biopsy is invasive and has some drawbacks, such as sampling error and intraobserver and interobserver variability in the assessment of fibrosis stages. Recently, various non-invasive tests such as serum markers, radiologic tests, and elastography have been investigated to overcome the limitations of liver biopsy. This review will focus on the use of these non-invasive tests for diagnosing liver cirrhosis.

Keyword

Liver cirrhosis; Liver biopsy; Shear wave

MeSH Terms

Biomarkers
Biopsy
Diagnosis*
Elasticity Imaging Techniques
Fibrosis
Liver Cirrhosis*
Liver*
Mortality
Observer Variation
Selection Bias
Biomarkers

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