Korean J Anesthesiol.  2017 Aug;70(4):420-425. 10.4097/kjae.2017.70.4.420.

Use of sugammadex in lung cancer patients undergoing video-assisted thoracoscopic lobectomy

• Cho HC
• Lee JH
• Lee SC
• Park SY
• Rim JC
• Choi SR

• KMID: 2386295
• DOI: http://doi.org/10.4097/kjae.2017.70.4.420

Abstract

BACKGROUND
This study aimed to retrospectively evaluate the use of sugammadex in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy.
METHODS
Data were obtained from medical record review of patients who underwent VATS lobectomy from January 2013 to November 2014. Fifty patients were divided into two groups: the sugammadex group (group S, n = 19) was administered sugammadex 2 mg/kg, while the pyridostigmine group (group P, n = 31) received pyridostigmine 20 mg with glycopyrrolate 0.2 mg or atropine 0.5 mg. The primary endpoint measure was the overall incidence of postoperative pulmonary complications including prolonged air leak, pneumonia, and atelectasis. The secondary endpoint measures were the length of postoperative hospital stay and duration of chest tube insertion.
RESULTS
The overall incidence of postoperative pulmonary complications in patients in group S was significantly lower compared with that of group P (5 [26.3%] vs. 17 [54.8%]; P = 0.049). Also, the durations of chest tube insertion (5.0 [4.0-7.0] vs. 7.0 [6.0-8.0] days; P = 0.014) and postoperative hospital stay (8.0 [8.0-10.0] vs. 10.0 [9.0-11.0] days; P = 0.019) were shorter in group S compared with group P. Administration of sugammadex was associated reduced with postoperative pulmonary complications (OR: 0.22; 95% CI: 0.05-0.87; P = 0.031).
CONCLUSIONS
The use of sugammadex, compared with pyridostigmine, showed a significantly reduced overall incidence of postoperative pulmonary complications and decreased duration of chest tube use and postoperative hospital stay in patients undergoing VATS lobectomy, suggesting that sugammadex might be helpful in improving clinical outcomes in such patients.

Keyword

Effect; Sugammadex; Thoracoscopic lobectomy; VATS lobectomy

MeSH Terms

Atropine
Chest Tubes
Glycopyrrolate
Humans
Incidence
Length of Stay
Lung Neoplasms*
Lung*
Medical Records
Pneumonia
Pulmonary Atelectasis
Pyridostigmine Bromide
Retrospective Studies
Thoracic Surgery, Video-Assisted
Atropine
Glycopyrrolate
Pyridostigmine Bromide