Nucl Med Mol Imaging.
2016 Dec;50(4):362-364. 10.1007/s13139-015-0383-8.
(99m)Tc-MIBI Uptake in a Thyroid Adenoma with Diffuse Adipose Metaplasia
- Affiliations
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- 1Department of Nuclear Medicine and PET/CT Centre, Oncology Institute of Southern Switzerland, via Ospedale, 12, 6500 Bellinzona, Switzerland. gaetano.paone@eoc.ch
- 2Institute of Pathology, Locarno, Switzerland.
- 3Department of Surgery, Beata Vergine Hospital, Mendrisio, Switzerland.
- KMID: 2386162
- DOI: http://doi.org/10.1007/s13139-015-0383-8
Abstract
- A 71-year-old female underwent a (99m)Tc- MIBI scan to characterize a cold nodule (30 mm) of the left thyroid lobe. The nodule showed diffuse uptake and retention of the radiotracer. After resection, histological examination demonstrated a microfollicular adenoma with diffuse white adipose metaplasia. Although mitochondria in brown adipose tissue have been widely studied, we have only a limited understanding of the relevance of mitochondria in white adipose tissue. Active mitochondria are present in white adipocytes, and this may account for the MIBI uptake, mimicking a hyperproliferation pattern, in our patient.
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