Clin Nutr Res.  2015 Oct;4(4):235-241. 10.7762/cnr.2015.4.4.235.

Association Between Usual Vitamin K Intake and Anticoagulation in Patients Under Warfarin Therapy

• Park JN
• Lee JS
• Noh MY
• Sung MK

• KMID: 2386080
• DOI: http://doi.org/10.7762/cnr.2015.4.4.235

Abstract

This study aimed to explore the correlation between usual vitamin K intake and response to anticoagulant therapy among patients under warfarin therapy. We conducted a retrospective survey of patients (n = 50) on continuous warfarin therapy. Clinical information and laboratory parameters were sourced from medical records. Anticoagulant effect was evaluated by using the percent time in therapeutic range (TTR) and the coefficient of variation (CV) of International normalized ratio (INR). Dietary vitamin K intake was assessed using a semi-quantitative food frequency questionnaire that has been developed for the purpose of assessing dietary intake of vitamin K. A total of 50 patients aged between 21 and 87 years were included in the study. The mean vitamin K intake was 262.8 +/- 165.2 microg/day. Study subjects were divided into tertiles according to their usual vitamin K intake. The proportion of men was significantly higher in second and third tertile than first tertile (p = 0.028). The mean percent TTR was 38.4 +/- 28.4% and CV of INR was 31.8 +/- 11.8%. Long-term warfarin therapy group (> or = 3 years) had a higher percentage of TTR as compared to the control group (< 3 years) (p = 0.046). No statistically significant correlation was found between usual vitamin K intake and percent TTR (p > 0.05). In conclusion, no significant association was observed between usual vitamin K intake and anticoagulant effects. Further studies are required to consider inter-individual variability of vitamin K intake. Development of assessment tools to measure inter-individual variability of vitamin K intake might be helpful.

Keyword

Warfarin; Vitamin K; Anticoagulant effect; Vitamin K antagonist

MeSH Terms

Humans
International Normalized Ratio
Male
Medical Records
Retrospective Studies
Vitamin K*
Vitamins*
Warfarin*
Vitamin K
Vitamins
Warfarin

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