Endocrinol Metab.  2014 Dec;29(4):410-417. 10.3803/EnM.2014.29.4.410.

Antiobesity Pharmacotherapy for Patients with Type 2 Diabetes: Focus on Long-Term Management

• Jeon WS
• Park CY

• KMID: 2384235
• DOI: http://doi.org/10.3803/EnM.2014.29.4.410

Abstract

Type 2 diabetes and obesity have a complex relationship; obesity is linked to insulin resistance, the precursor to type 2 diabetes. The management of obesity is an important method to delay onset of diabetes and improve the glycemic durability of antidiabetic agents. However, insulin and some of the oral hypoglycemic agents used to treat diabetes cause significant weight gain, and it is difficult for patients with diabetes to reduce and maintain their weight by life-style changes alone. Thus, antiobesity medications or bariatric surgery may be a necessary adjunct for certain obese patients with diabetes. In 2012, the U.S. Food and Drug Administration (FDA) approved lorcaserin and phentermine/topiramate extended-release for the management of chronic weight, and approval for naltrexone/bupropion sustained-release as an adjunct to exercise and reduced caloric intake followed in 2014. Liraglutide is pending FDA approval for antiobesity drug. Here we review the efficacy of approved and new promising drugs for the management of obesity.

Keyword

Obesity; Drug therapy; Diabetes

MeSH Terms

Bariatric Surgery
Drug Therapy*
Energy Intake
Humans
Hypoglycemic Agents
Insulin
Insulin Resistance
Obesity
United States Food and Drug Administration
Weight Gain
Liraglutide
Hypoglycemic Agents
Insulin

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