Endocrinol Metab.  2017 Jun;32(2):288-295. 10.3803/EnM.2017.32.2.288.

Poorly Differentiated Thyroid Carcinoma: 10-Year Experience in a Southeast Asian Population

• Yu MG
• Rivera J
• Jimeno C

• KMID: 2384089
• DOI: http://doi.org/10.3803/EnM.2017.32.2.288

Abstract

BACKGROUND
No previous studies have been published on poorly differentiated thyroid carcinoma (PDTC) in Southeast Asia.
METHODS
We included all adult PDTC patients diagnosed using the Turin criteria at the Philippine General Hospital from 2006 to 2015. The data collected included demographics, clinical presentation, histopathology, treatment, and outcomes. Tests of association were employed to compare these data with foreign studies on PDTC, as well as with local studies on well differentiated thyroid carcinoma (WDTC) and anaplastic thyroid carcinoma (ATC).
RESULTS
Eighteen PDTC cases were identified. The median age was 62 years old, with the majority being females. All patients had goiter on presentation, and most were stage IV at the time of diagnosis. In terms of PDTC subtype, insular and trabecular patterns were equally common. Extrathyroidal extension was documented in eight patients, while five patients each had nodal and distant metastasis. All but one patient underwent surgery; however, less than half received adjuvant radioiodine therapy. The 5-year survival rate was 83%. Three patients (16.7%) died at a median of 12 months after diagnosis. Nine (50%) are still alive with persistent and/or recurrent disease at a median of 39 months after diagnosis.
CONCLUSION
The behavior of PDTC in this Southeast Asian population was found to be similar to patterns observed in other regions, and exhibited intermediate features between WDTC and ATC. Appropriate surgery provided excellent 5-year survival rates, but the role of adjuvant therapy remains unclear. Larger studies are needed to identify prognostic factors in this population.

Keyword

Adult; Humans; Thyroid neoplasms; Philippines; Survival rate; Retrospective studies

MeSH Terms

Adult
Asia, Southeastern
Asian Continental Ancestry Group*
Demography
Diagnosis
Female
Goiter
Hospitals, General
Humans
Neoplasm Metastasis
Philippines
Retrospective Studies
Survival Rate
Thyroid Carcinoma, Anaplastic
Thyroid Gland*
Thyroid Neoplasms*

Figure

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  Fig. 1 Survival curves of Filipino patients after poorly differentiated thyroid carcinoma (PDTC) diagnosis.

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