Ann Pediatr Endocrinol Metab.  2017 Jun;22(2):95-101. 10.6065/apem.2017.22.2.95.

The influence of gonadotropin releasing hormone agonist treatment on the body weight and body mass index in girls with idiopathic precocious puberty and early puberty

Affiliations
  • 1Department of Pediatrics, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea. chungwy@chol.com

Abstract

PURPOSE
This study aimed to investigate the influence of gonadotropin releasing hormone agonist (GnRHa) treatment on the weight and body mass index (BMI) of girls who were diagnosed with idiopathic central precocious puberty (CPP) or early puberty (EP).
METHODS
Patients who were younger than 8 years of age at diagnosis were classified as CPP and patients aged between 8 and 9 years at diagnosis were classified as EP. Of 129 patients, 34 were diagnosed with CPP and 95 were diagnosed with EP. The patients were divided according to pretreatment weight status into normal weight group, an overweight group, or an obese group.
RESULTS
No significant changes were observed with respect to the weight standard deviation score (SDS) before and after 1 year, 2 years of treatment, respectively (P>0.05, P>0.05) in all patient groups. No significant changes were observed in relation to the BMI SDS before and after 1 year, 2 years of treatment, respectively (P>0.05, P>0.05) in all patient group. Depending on the degree of obesity, differences with respect to the weight SDS and BMI SDS were observed.
CONCLUSION
BMI SDS increased in the GnRHa-treated patients as a whole group, but was not statistically significant. But BMI SDS increased significantly in the normal weight group after 2 years of GnRHa treatment. So, GnRHa treatment may affect the change of BMI SDS depending on degree of obesity.

Keyword

Gonadotropin-releasing hormone; Body weight; Body mass index; Central precocious puberty; Precocious puberty

MeSH Terms

Adolescent
Body Mass Index*
Body Weight*
Diagnosis
Female*
Gonadotropin-Releasing Hormone*
Gonadotropins*
Humans
Obesity
Overweight
Puberty*
Puberty, Precocious*
Gonadotropin-Releasing Hormone
Gonadotropins

Cited by  1 articles

Changes in body mass index in boys with central precocious puberty over 2 years of gonadotropin-releasing hormone agonist therapy
Kyung In Lim, Hae Sang Lee, Jin Soon Hwang
Ann Pediatr Endocrinol Metab. 2020;25(3):169-173.    doi: 10.6065/apem.1938176.088.


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