- The utilization of basal luteinizing hormone in combination with the basal luteinizing hormone and follicle-stimulating hormone ratio as a diagnostic tool for central precocious puberty in girls
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Chotipakornkul N, Onsoi W, Numsriskulrat N, Aroonparkmongkol S, Supornsilchai V, Srilanchakon K
- KMID: 2543295
- Ann Pediatr Endocrinol Metab.
- 2023 Jun;28(2):138-143.
- doi: 10.6065/apem.2346072.036
Purpose: Intravenous gonadotropin-releasing hormone (IV GnRH) testing is the gold standard for confirming a central precocious puberty (CPP) diagnosis. However, this test is not widely available commercially. Therefore, our study... -
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- Effect of gonadotropin-releasing hormone agonist treatment on near final height in girls with central precocious puberty and early puberty
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Yang EH, Jo HY, Park SJ, Yoo HW, Choi SH, Kim HY, Park KH, Kim YM, Kwak MJ
- KMID: 2540787
- Ann Pediatr Endocrinol Metab.
- 2023 Mar;28(1):49-53.
- doi: 10.6065/apem.2142250.125
Purpose: The aim of this study was to examine whether gonadotropin-releasing hormone (GnRH) agonist treatment is effective in preserving final height in patients with central precocious puberty (CPP) or early... -
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- Adrenocortical carcinoma and a sporadic MEN1 mutation in a 3-year-old girl: a case report
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Kim SE, Lee NY, Cho WK, Yim J, Lee JW, Kim M, Chung JH, Jung MH, Suh BK, Ahn MB
- KMID: 2537244
- Ann Pediatr Endocrinol Metab.
- 2022 Dec;27(4):315-319.
- doi: 10.6065/apem.2142100.050
Childhood adrenocortical carcinoma (ACC) is a rare disease that is mostly linked to familial cancer syndrome. Although the prevalence of ACC is extremely low in children, it is clinically important... -
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- Central Precocious Puberty Following Treatment of Precocious Pseudo-Puberty Caused by Leydig Cell Tumor: A Pediatric Case and Literature Review
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Ahn JH, Park JK, Jung SJ, Lee JE
- KMID: 2534767
- Clin Pediatr Hematol Oncol.
- 2022 Oct;29(2):74-78.
- doi: 10.15264/cpho.2022.29.2.74
Leydig cell tumors can cause precocious puberty in prepubertal males. Radical orchiectomy is the standard therapy for Leydig cell tumors, with a good overall prognosis. Here, we present a rare case... -
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- Clinical Usefulness of Pelvic Ultrasound in Diagnosis of Precocious Puberty
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Kim DH, Jung SY, Lee J
- KMID: 2531504
- Soonchunhyang Med Sci.
- 2022 Jun;28(1):28-32.
- doi: 10.15746/sms.22.005
Objective: Precocious puberty is the adrenarche that occurs before the age of 8 in girls. Gonadotropin-releasing hormone stimulation test (GnRH stimulation test), which is widely used in diagnosing precocious puberty,... -
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- Pathological brain lesions in girls with central precocious puberty at initial diagnosis in Southern Vietnam
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Huynh QTV, Ho BT, Le NQK, Trinh TH, Lam LHT, Nguyen NTK, Huang SY
- KMID: 2531274
- Ann Pediatr Endocrinol Metab.
- 2022 Jun;27(2):105-112.
- doi: 10.6065/apem.2142146.073
Purpose: Cranial magnetic resonance imaging (MRI) is recommended to identify intracranial lesions in girls with central precocious puberty (CPP). Yet, the use of routine MRI scans in girls with CPP... -
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- Genetic factors in precocious puberty
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Shim YS, Lee HS, Hwang JS
- KMID: 2528234
- Clin Exp Pediatr.
- 2022 Apr;65(4):172-181.
- doi: 10.3345/cep.2021.00521
Pubertal onset is known to result from reactivation of the hypothalamic-pituitary-gonadal (HPG) axis, which is controlled by complex interactions of genetic and nongenetic factors. Most cases of precocious puberty (PP)... -
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- Association of Early Pubertal Onset in Female Rats With Inhalation of Lavender Oil
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Kim YM, Lim HH
- KMID: 2524294
- J Korean Med Sci.
- 2022 Jan;37(2):e9.
- doi: 10.3346/jkms.2022.37.e9
Background: Central precocious puberty (CPP) is caused by early activation of the hypothalamic–pituitary–gonadal axis but its major cause remains unclear. Studies have indicated an association between chronic environmental exposure to... -
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- Effects of gonadotropin-releasing hormone agonist treatment on final adult height in boys with idiopathic central precocious puberty
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Cho AY, Ko SY, Lee JH, Kim EY
- KMID: 2523832
- Ann Pediatr Endocrinol Metab.
- 2021 Dec;26(4):259-265.
- doi: 10.6065/apem.2040268.134
Purpose: There are few reports on the therapeutic effects of gonadotropin-releasing hormone agonists in boys with central precocious puberty, and studies reported in Korea are very rare. We aimed to... -
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- Diagnosis and Treatment of Central Precocious Puberty
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Choi HS, Kim HS, Chae HW
- KMID: 2521820
- Ewha Med J.
- 2021 Oct;44(4):117-121.
- doi: 10.12771/emj.2021.44.4.117
A notable secular trend in early puberty onset has been described over the past few decades. Also, the prevalence and incidence of precocious puberty is increasing not only in Korea,... -
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- An 8-year-old girl with drug hypersensitivity to first triptorelin acetate administration
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Jung N, Lee JE, Lim DH, Kim JH
- KMID: 2521777
- Allergy Asthma Respir Dis.
- 2021 Oct;9(4):255-258.
- doi: 10.4168/aard.2021.9.4.255
Triptorelin is a synthetic gonadotropin-releasing hormone agonist for the treatment of precocious puberty in children. Among the triptorelin side effects, drug hypersensitivity reactions, including anaphylaxis, can rarely occur, mostly after... -
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- Clinical findings influencing time to menarche post gonadotropin-releasing hormone agonist therapy in central precocious puberty
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Wu V, Zhao V, Issa R, Wilkes M, Wallach E, Rapaport R, Romero C, Yau M
- KMID: 2520511
- Ann Pediatr Endocrinol Metab.
- 2021 Sep;26(3):185-191.
- doi: 10.6065/apem.2040220.110
Purpose: This study aimed to evaluate the time interval to menarche after gonadotropin-releasing hormone agonist (GnRHa) treatment in females with central precocious puberty (CPP) and to identify factors contributing to... -
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- Single random measurement of urinary gonadotropin concentration for screening and monitoring girls with central precocious puberty
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Lee SY, Kim JM, Kim YM, Lim HH
- KMID: 2520510
- Ann Pediatr Endocrinol Metab.
- 2021 Sep;26(3):178-184.
- doi: 10.6065/apem.2040208.104
Purpose: The gold standard for assessing pubertal activation is the gonadotropinreleasing hormone (GnRH) stimulation test (GnRHST), which is invasive, timeconsuming, and inconvenient. This study evaluated whether a single random measurement... -
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- Short-term efficacy of 1-month and 3-month gonadotropin-releasing hormone agonist depots in girls with central precocious puberty
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Jeon MJ, Choe JW, Chung HR, Kim JH
- KMID: 2520509
- Ann Pediatr Endocrinol Metab.
- 2021 Sep;26(3):171-177.
- doi: 10.6065/apem.2040134.067
Purpose: Gonadotropin-releasing hormone agonist (GnRHa) has been the mainstay of central precocious puberty (CPP) treatment for decades, but few reports have compared the efficacy of 1-month and 3-month depot GnRHa... -
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- Efficacy of Triptorelin 3-Month Depot Compared to 1-Month Depot for the Treatment of Korean Girls with Central Precocious Puberty in Single Tertiary Center
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Chung LY, Kang E, Nam HK, Rhie YJ, Lee KH
- KMID: 2519595
- J Korean Med Sci.
- 2021 Aug;36(34):e219.
- doi: 10.3346/jkms.2021.36.e219
Background: Triptorelin depot is largely used to treat central precocious puberty (CPP) in children, and a 3-month depot has been introduced. However, data about the 3-month gonadotropin-releasing hormone use for... -
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- Relationship between growth velocity and change of levels of insulin-like growth factor-1, insulin-like growth factor binding protein-3 and, IGFBP-3 promoter polymorphism during GnRH agonist treatment
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Park JH, Hwang IT, Yang S
- KMID: 2510894
- Ann Pediatr Endocrinol Metab.
- 2020 Dec;25(4):234-239.
- doi: 10.6065/apem.2040020.010
Purpose: This study aims to investigate the effect of gonadotropin-releasing hormone agonist (GnRHa) on the growth hormone (GH)-insulin-like growth factor-1 (IGF-1) axis and to evaluate whether -202 A/C IGF binding... -
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- The Effect of Combined Growth Hormone and a Gonadotropin-Releasing Hormone Agonist Therapy on Height in Korean 3-M Syndrome Siblings
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Lee IK, Lim HH, Kim YM
- KMID: 2507820
- Yonsei Med J.
- 2020 Nov;61(11):981-985.
- doi: 10.3349/ymj.2020.61.11.981
3-M syndrome is a rare autosomal recessive growth disorder characterized by severe growth retardation, low birth weight, characteristic facial features, and skeletal anomalies, for which three causative genes (CUL7, OBSL1,... -
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- Incidental Findings on Brain Magnetic Resonance Imaging in Children with Central Precocious Puberty
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Kim JY, Lee JH, Cho HH, Kim HS
- KMID: 2507779
- Ewha Med J.
- 2020 Oct;43(4):53-59.
- doi: 10.12771/emj.2020.43.4.53
Objectives: To investigate brain magnetic resonance imaging (MRI) findings in patients with central precocious puberty (CPP) by age at onset and sex. Methods: We included 130 CPP patients with brain MRI... -
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- Changes in body mass index in boys with central precocious puberty over 2 years of gonadotropin-releasing hormone agonist therapy
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Lim KI, Lee HS, Hwang JS
- KMID: 2507559
- Ann Pediatr Endocrinol Metab.
- 2020 Sep;25(3):169-173.
- doi: 10.6065/apem.1938176.088
Purpose: Gonadotropin-releasing hormone agonist (GnRHa) is a safe and effective therapy used to treat central precocious puberty (CPP). Although most studies have reported no significant difference in body mass index... -
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- Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty: a mini review
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Ab Rahim SN, Omar J, Tuan Ismail TS
- KMID: 2507556
- Ann Pediatr Endocrinol Metab.
- 2020 Sep;25(3):152-155.
- doi: 10.6065/apem.2040004.002
The gonadotropin-releasing hormone (GnRH) stimulation test is a valuable tool in diagnosing and differentiating causes of early pubertal occurrences. Utility of the test can be limited in some instances, however,... -
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