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Changes in body mass index in boys with central precocious puberty over 2 years of gonadotropin-releasing hormone agonist therapy

Lim KI, Lee HS, Hwang JS

Purpose: Gonadotropin-releasing hormone agonist (GnRHa) is a safe and effective therapy used to treat central precocious puberty (CPP). Although most studies have reported no significant difference in body mass index...
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Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty: a mini review

Ab Rahim SN, Omar J, Tuan Ismail TS

The gonadotropin-releasing hormone (GnRH) stimulation test is a valuable tool in diagnosing and differentiating causes of early pubertal occurrences. Utility of the test can be limited in some instances, however,...
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Evaluation of Characteristics of the Dental Maturity in Girls with Precocious Puberty

Kim CH, Kang CM, Kim IH, Song JS, Kim SO

Precocious puberty (PP) is defined as the early development of secondary sexual characteristics (before the ages of 8 years in girls and 9 years in boys). The aim of this...
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Prevalence of idiopathic scoliosis in girls with central precocious puberty: effect of a gonadotropin-releasing hormone agonist

Chung LY, Nam HK, Rhie YJ, Huh R, Lee KH

Purpose: Adolescent idiopathic scoliosis (AIS) is the most common form of scoliosis and occurs in children between 10 to 18 years old, during periods of growth spurts and puberty changes....
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Evaluation of cephalometric characteristics and skeletal maturation of the cervical vertebrae and hand-wrist in girls with central precocious puberty

Kang ST, Choi SH, Kim KH, Hwang CJ

Objective: This study aimed to evaluate the differences in cephalometric characteristics and skeletal maturation in girls with central precocious puberty (CPP) via lateral and hand-wrist radiographs. We also aimed to...
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Effect of agricultural pesticide on precocious puberty in urban children: an exploratory study

Suh J, Choi HS, Kwon A, Chae HW, Kim HS

Background: The incidence of precocious puberty has increased throughout the 20th century. The association between precocious puberty and endocrine disrupting chemicals including agricultural pesticides has been a subject of global...
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Relationship between final adult height and birth weight after gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty

Cho AY, Ko SY, Lee JH, Kim EY

Purpose: The clinical significance of birth weight relative to gestational age in girls with central precocious puberty is unclear. This study sought to compare clinical parameters such as final adult...
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Relationship between growth velocity and change of levels of insulin-like growth factor-1, insulin-like growth factor binding protein-3 and, IGFBP-3 promoter polymorphism during GnRH agonist treatment

Park JH, Hwang IT, Yang S

Purpose: This study aims to investigate the effect of gonadotropin-releasing hormone agonist (GnRHa) on the growth hormone (GH)-insulin-like growth factor-1 (IGF-1) axis and to evaluate whether -202 A/C IGF binding...
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The Effect of Combined Growth Hormone and a Gonadotropin-Releasing Hormone Agonist Therapy on Height in Korean 3-M Syndrome Siblings

Lee IK, Lim HH, Kim YM

3-M syndrome is a rare autosomal recessive growth disorder characterized by severe growth retardation, low birth weight, characteristic facial features, and skeletal anomalies, for which three causative genes (CUL7, OBSL1,...
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Incidental Findings on Brain Magnetic Resonance Imaging in Children with Central Precocious Puberty

Kim JY, Lee JH, Cho HH, Kim HS

Objectives: To investigate brain magnetic resonance imaging (MRI) findings in patients with central precocious puberty (CPP) by age at onset and sex. Methods: We included 130 CPP patients with brain MRI...
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Association of maxillary dental developmental abnormality with precocious puberty: a case-control study

Kim Y, Lee NK, Kim JH, Ku JK, Lee BK, Jung HI, Choi SK

Background Dental studies of precocious puberty have focused on examination of jaw and dentition growth. The aim of the study was to analyze the relationship between precocious puberty and maxillary dental...
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Basal serum luteinizing hormone value as the screening biomarker in female central precocious puberty

Heo S, Lee YS, Yu J

PURPOSE: Precocious puberty refers to the development of secondary sex characteristics before ages 8 and 9 years in girls and boys, respectively. Central precocious puberty (CPP) is caused by premature...
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Methylphenidate and Central Precocious Puberty: A Probable Side Effect among Seven Children with the Attention Deficit Hyperactivity Disorder

Ergür AT, Gül H, Gül A

Methylphenidate (MPH) is the most preferred drug for treatment of the attention deficit hyperactivity disorder (ADHD). Here, we aimed to discuss the possible effects and mechanisms of MPH on precocious...
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Thyroid function in girls with central precocious puberty

Jung G, Oh SB, Lee WY, Kim HR, Nam HK, Kim JH, Rhie YJ, Lee KH

PURPOSE: Obesity is a well-known risk factor for central precocious puberty (CPP). Recently, elevated thyroid stimulating hormone (TSH) was reported in obese youth. However, few data regarding the relationship between...
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Episodes of prolonged “trance-like state” in an infant with hypothalamic hamartoma

Kumar R, Yadav J, Sahu JK, Tripathi M, Ahuja C, Dayal D

Hypothalamic hamartoma (HH) is one of the most common causes of central precocious puberty (CPP) in first few years of life. It can present with either seizures or CPP, although...
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Morning basal luteinizing hormone, a good screening tool for diagnosing central precocious puberty

Lee DM, Chung IH

PURPOSE: The standard method used to diagnose central precocious puberty (CPP) is the gonadotropin releasing hormone stimulation test (GnRHST). However, this test is inconvenient for children because it is time-consuming...
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Experiences of Precocious Puberty in Primary School Girls with Hormone Therapeutics

Cheon SM, Jung HY

PURPOSE: The purpose of this qualitative study was to identify the nature of precocious puberty and to explore what it means in primary schools. METHODS: The participants of this phenomenological study...
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Herlyn-Werner-Wunderlich Syndrome with Central Precocious Puberty: A Case Report

Han J, Lee JM, Kim GH, Kim SJ

Herlyn-Werner-Wunderlich (HWW) syndrome is a rare congenital anomaly of the genitourinary tract comprising uterus didelphys, obstructed hemivagina, and ipsilateral renal agenesis. Patients with HWW syndrome usually present symptoms such as...
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Depression and Fear about Maturation in Girls with Precocious Puberty and Depression and Anxiety in Their Mothers

Lee MJ, Baek SH, Park SA

PURPOSE: This study investigated depression and anxiety in girls with precocious puberty and in their mothers. METHOD: This study recruited 75 girls treated with a gonadotropin-releasing hormone agonist (GnRHa) and their...
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Visceral fat thickness and its associations with pubertal and metabolic parameters among girls with precocious puberty

Kim DW, Suh J, Kwon AR, Chae HW, Yoon CS, Kim HS, Kim DH

PURPOSE: This study aimed to investigate associations of central obesity with sexual maturation and metabolic parameters in Korean girls with precocious puberty. METHODS: This retrospective study evaluated data from 72 girls...
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