Korean J Helicobacter Up Gastrointest Res.
2017 Jun;17(2):88-93. 10.7704/kjhugr.2017.17.2.88.
Clinicopathological Characteristics of Gastric Hepatoid Adenocarcinoma
- Affiliations
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- 1Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. doc0224@pusan.ac.kr
- 2Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
- 3Department of Pathology, Pusan National University School of Medicine, Busan, Korea.
- KMID: 2383587
- DOI: http://doi.org/10.7704/kjhugr.2017.17.2.88
Abstract
- BACKGROUND/AIMS
Gastric hepatoid adenocarcinoma (GHA), a rare type of primary gastric cancer, is characterized by a histology resembling hepatocellular carcinoma. Previous case studies reported that patients with GHA have a poor prognosis due to early lymph node or liver metastasis, but information concerning GHA is still limited. Therefore, we aimed to evaluate the clinicopathological features of GHA.
MATERIALS AND METHODS
We reviewed the medical records of 9 patients who were diagnosed as having GHA between January 2011 and December 2016. The clinicopathological characteristics of these patients were retrospectively analyzed.
RESULTS
The median age of the patients at diagnosis was 68.9 years. Seven of the 9 patients were male. Serum AFP levels were elevated in 3 of 4 patients. All the tumors were >4 cm (range, 4~12 cm), and 7 tumors were located at the lower third of the stomach. Five tumors were classified as Borrmann's type 3, with a purple, berry-like surface. Of the 6 patients without distant metastasis, 5 received curative-intent surgery and 3 received adjuvant chemotherapy. Three patients with distant metastasis received either palliative operation and/or chemotherapy. Their median survival time was 11.8 months (range, 1~36 months). Two patients with elevated serum CEA levels had poor outcomes.
CONCLUSIONS
GHA is a rare subtype of gastric cancer that is prone to liver metastasis. All GHAs are advanced gastric cancer with a purple, berry-like surface at diagnosis. Although the prognosis of advanced-stage GHA is poor, active multimodality treatment might provide some benefit.
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