Korean J Pathol.
1994 Aug;28(4):409-413.
Gagtric Adenocarcinoma with Choriocarcinomatous and Hepatoid Differentiation: Report of a case
- Affiliations
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- 1Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
- 2Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
Abstract
- Association of the hepatoid and choriocarcinomatous components in adenocarcinoma of the stomach is extremely unusual and raises a possibility of new approach understand the histogenesis of gastric hepatoid adenocarcinoma. This paper describes a Borrmann type III adenocarcinoma of the stomach with both choriocarcinomatous and hepatoid components in composite tumor pattern in a 50-year-old man. Tubular arrangement of differentiated embryonalcarcinoma was encountered in choricarcinomatous and hepatoid areas, which showed strong immunoreactivity to beta-HCG and AFP, respectively. The findings suggest that gastric adenocarcinoma may have a potential of differentiation toward embryonal carcinoma. from which both choriocarcinoma and hepatoid variant of gastric adenocarcinoma may develop by retrodifferentiation.
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