Korean J Gastrointest Endosc.  2010 Dec;41(6):355-359.

A Case of Gastric Undifferentiated Carcinoma with Choriocarcinomatous and Hepatoid Carcinomatous Differentiation

• Lee SY
• Moon HS
• Kim ES
• Kim YJ
• Goh PG
• Lee BS
• Jeong HY
• Lee HY

Abstract

Here we report a case of a patient with gastric undifferentiated carcinoma associated with choriocarcinomatous and hepatoid carcinomatous differentiation. A 62-year-old man was referred after a healthcare screening gastroscopy. Gastroscopy revealed an approximately 3x3 cm ulcerofungating mass in the posterior wall of the antrum. Biopsy results revealed a moderately differentiated adenocarcinoma. The initial serum alpha-FP levels were above 350 ng/mL. An abdominal CT scan revealed focal wall thickening along the greater curvature of the gastric antrum, with perigastric fat invasion and enlarged multiple perigastric lymph nodes. He underwent a palliative radical subtotal gastrectomy and gastroduodenostomy with dissection of the enlarged lymph nodes. Postsurgical histological examination revealed an undifferentiated carcinoma associated with choriocarcinomatous and hepatoid carcinomatous differentiation. Immunohistochemical staining revealed that the tumor cells were positive for human chorionic gonadotropin (hCG), alpha-FP, and anti-hepatocyte antibody.

Keyword

Gastric undifferentiated carcinoma; Hepatoid carcinoma; Choriocarcinoma

MeSH Terms

Adenocarcinoma
Biopsy
Carcinoma
Choriocarcinoma
Chorionic Gonadotropin
Delivery of Health Care
Female
Gastrectomy
Gastroscopy
Humans
Lymph Nodes
Mass Screening
Middle Aged
Pregnancy
Pyloric Antrum
Chorionic Gonadotropin