Lab Med Online.  2017 Jul;7(3):157-160. 10.3343/lmo.2017.7.3.157.

A Case of Streptococcus gallolyticus subsp. gallolyticus Bacteremia in Liver Cirrhosis

Affiliations
  • 1Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. u931018@yonsei.ac.kr

Abstract

Streptococcus bovis bacteremia in humans has been traditionally associated with infective endocarditis, colorectal cancer, and liver cirrhosis. S. bovis strains were previously categorized by biotype, but since the 2000s, they have been reclassified by DNA homology. We report a case of S. gallolyticus subsp. gallolyticus bacteremia, identified by 16S rRNA sequencing, in a patient diagnosed with liver cirrhosis. A 61-yr-old man with a history of liver cirrhosis presented to the hospital with a complaint of fever. Blood culture revealed the presence of gram-positive cocci, and the isolated organism was identified as S. bovis by the MicroScan identification kit (Beckman Coulter, USA), but as Enterococcus saccharolyticus by the Vitek 2 identification kit (bioMérieux, USA). The organism was finally confirmed as S. gallolyticus subsp. gallolyticus by 16S rRNA sequencing.

Keyword

Bacteremia; Liver cirrhosis; Streptococcus gallolyticus; 16S rRNA sequencing

MeSH Terms

Bacteremia*
Colorectal Neoplasms
DNA
Endocarditis
Enterococcus
Fever
Gram-Positive Cocci
Humans
Liver Cirrhosis*
Liver*
Streptococcus bovis
Streptococcus*
DNA

Reference

1. Zammit SC, Azzopardi N, Ellul P. Streptococcus gallolyticus bacteraemia in hepatobiliary-pancreatic and colonic pathologies. QJM. 2014; 107:355–61.
Article
2. Spellerberg B, Brandt C. Streptococcus. Jorgensen JH, editor. Manual of clinical microbiology. 11th ed.Washington, D.C.: ASM Press;2015. p. 383–402.
Article
3. Corredoira J, Alonso MP, Garcia-Garrote F, Garcia-Pais MJ, Coira A, Rabunal R, et al. Streptococcus bovis group and biliary tract infections: an analysis of 51 cases. Clin Microbiol Infect. 2014; 20:405–9.
Article
4. Lazarovitch T, Shango M, Levine M, Brusovansky R, Akins R, Hayakawa K, et al. The relationship between the new taxonomy of Streptococcus bovis and its clonality to colon cancer, endocarditis, and biliary disease. Infection. 2013; 41:329–37.
Article
5. Klein RS, Recco RA, Catalano MT, Edberg SC, Casey JI, Steigbigel NH. Association of Streptococcus bovis with carcinoma of the colon. N Engl J Med. 1977; 297:800–2.
6. Klein RS, Catalano MT, Edberg SC, Casey JI, Steigbigel NH. Streptococcus bovis septicemia and carcinoma of the colon. Ann Intern Med. 1979; 91:560–2.
Article
7. Atkin WS, Morson BC, Cuzick J. Longterm risk of colorectal cancer after excision of rectosigmoid adenomas. N Engl J Med. 1992; 326:658–62.
Article
8. Devis A, Dony A, De Boelpaepe F, Verhulst C, Sersté JP. Streptococcus bovis septicemia and colonic cancer. Acta Chir Belg. 1989; 89:58–60.
9. Abdulamir AS, Hafdh RR, Mahdi LK, Al-jeboori T, Abubaker F. Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenoma. BMC Cancer. 2009; 9:403.
Article
10. Biarc J, Nguyen IS, Pini A, Gossé F, Richert S, Thiersé D, et al. Carcinogenic properties of proteins with pro-infammatory activity from Streptococcus infantarius (formerly S. bovis). Carcinogenesis. 2004; 25:1477–84.
11. Tripodi MF, Adinolf LE, Ragone E, Durante Mangoni E, Fortunato R, Iarussi D, et al. Streptococcus bovis endocarditis and its association with chronic liver disease: an underestimated risk factor. Clin Infect Dis. 2004; 38:1394–400.
Article
12. Zarkin BA, Lillemoe KD, Cameron JL, Effron PN, Magnuson TH, Pitt HA. The triad of Streptococcus bovis bacteremia, colonic pathology, and liver disease. Ann Surg. 1990; 211:786–91.
Article
13. Beck M, Frodl R, Funke G. Comprehensive study of strains previously designated Streptococcus bovis consecutively isolated from human blood cultures and emended description of Streptococcus gallolyticus and Streptococcus infantarius subsp. coli. J Clin Microbiol. 2008; 46:2966–72.
14. Schlegel L, Grimont F, Ageron E, Grimont PA, Bouvet A. Reappraisal of the taxonomy of the Streptococcus bovis/Streptococcus equinus complex and related species: description of Streptococcus gallolyticus subsp. gallolyticus subsp. nov., S. gallolyticus subsp. macedonicus subsp. nov. and S. gallolyticus subsp. pasteurianus subsp. nov. Int J Syst Evol Microbiol. 2003; 53:631–45.
15. Schlegel L, Grimont F, Collins MD, Régnault B, Grimont PA, Bouvet A. Streptococcus infantarius sp. nov., Streptococcus infantarius subsp. infantarius subsp. nov. and Streptococcus infantarius subsp. coli subsp. nov., isolated from humans and food. Int J Syst Evol Microbiol. 2000; 50:1425–34.
Article
16. Kim SY, Joo SI, Yi J, Kim EC. A case of Streptococcus gallolyticus subsp. gallolyticus infective endocarditis with colon cancer: identifcation by 16S ribosomal DNA sequencing. Korean J Lab Med. 2010; 30:160–5.
17. Park JW, Eun SH, Kim EC, Seong MW, Kim YK. Neonatal invasive Streptococcus gallolyticus subsp. pasteurianus infection with delayed central nervous system complications. Korean J Pediatr. 2015; 58:33–6.
18. Uh Y, Kwon O, Yoon KJ, Hwang GY, Kim HY. Underlying diseases associated with Streptococcus bovis bacteremia and antimicrobial susceptibility of the organism. Korean J Clin Microbiol. 2006; 9:36–41.
Full Text Links
  • LMO
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr