Gut Liver.  2016 Jan;10(1):133-139. 10.5009/gnl14506.

Visceral Obesity If Associated with Gallbladder Polyps

• Lee JK
• Hahn SJ
• Kang HW
• Jung JG
• Choi HS
• Lee JH
• Han IW
• Jung JH
• Kwon JH

• KMID: 2382354
• DOI: http://doi.org/10.5009/gnl14506

Abstract

BACKGROUND/AIMS
Gallbladder polyps (GBP) are a common clinical finding and may possess malignant potential. We conducted this study to determine whether visceral obesity is a risk factor for GBP.
METHODS
We retrospectively reviewed records of subjects who received both ultrasonography and computed tomography with measurements of the areas of visceral adipose tissue and total adipose tissue (TAT) on the same day as health checkups.
RESULTS
Ninety-three of 1,615 subjects (5.8%) had GBP and were compared with 186 age- and sex-matched controls. VAT (odds ratio [OR], 2.941; 95% confidence interval [CI], 1.325 to 6.529; p=0.008 for the highest quartile vs the lowest quartile) and TAT (OR, 3.568; 95% CI, 1.625 to 7.833; p=0.002 for the highest quartile vs the lowest quartile) were independent risk factors together with hypertension (OR, 2.512; 95% CI, 1.381 to 4.569; p=0.003), diabetes mellitus (OR, 2.942; 95% CI, 1.061 to 8.158; p=0.038), hepatitis B virus positivity (OR, 3.548; 95% CI, 1.295 to 9.716; p=0.014), and a higher level of total cholesterol (OR, 2.232; 95% CI, 1.043 to 4.778; p=0.039 for <200 mg/dL vs > or =240 mg/dL). Body mass index and waist circumference were not meaningful variables.
CONCLUSIONS
Visceral obesity measured by VAT and TAT was associated with GBP irrespective of body mass index or waist circumference.

Keyword

Gallbladder polyp; Obesity, abdominal; Adipose tissue; Metabolic syndrome; Risk factors

MeSH Terms

Adipose Tissue/ultrasonography
Adult
Case-Control Studies
Cholesterol/blood
Diabetes Complications
Female
Gallbladder Diseases/blood/epidemiology/*etiology
Hepatitis B/complications
Humans
Hypertension/complications
Intra-Abdominal Fat/ultrasonography
Male
Middle Aged
Obesity, Abdominal/blood/*complications/ultrasonography
Odds Ratio
Polyps/blood/epidemiology/*etiology
Prevalence
Retrospective Studies
Risk Factors
Cholesterol