Maxillofac Plast Reconstr Surg.  2015 Nov;37(11):41. 10.1186/s40902-015-0042-0.

Manifestation and treatment in a cleidocranial dysplasia patient with a RUNX2 (T420I) mutation

• Lee C
• Jung HS
• Baek JA
• Leem DH
• Ko SO

• KMID: 2381867
• DOI: http://doi.org/10.1186/s40902-015-0042-0

Abstract

Cleidocranial dysplasia is an autosomal dominant heritable skeletal disorder. The characteristic features of cleidocranial dysplasia (CCD) may include hypoplasia of the clavicle, delayed closure of frontanelles, late tooth eruption, and other skeletal disorders. This case report describes clinical and radiographic manifestations at the age of 11 and 29 of a CCD patient, investigates the mutation of core-binding factor A1 (CBFA1) based on gene analysis, and illustrates successful oral reconstruction with fixed prosthesis and dental implant after the extraction of multiple teeth.

Keyword

Cleidocranial dysplasia; CCD; Cleidocranial dysostosis; RUNX2 gene mutation (T420I)

MeSH Terms

Clavicle
Cleidocranial Dysplasia*
Core Binding Factors
Dental Implants
Humans
Prostheses and Implants
Tooth
Tooth Eruption
Core Binding Factors
Dental Implants