Int Neurourol J.
2015 Jun;19(2):107-112. 10.5213/inj.2015.19.2.107.
Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study
- Affiliations
-
- 1Department of Urology, Ajou University School of Medicine, Suwon, Korea. predoc@naver.com
- 2Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
- 3Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 4Department of Urology, Chonbuk National University Medical School, Jeonju, Korea.
- 5Department of Urology, Chonnam National University Medical School, Gwangju, Korea.
- 6Department of Urology, Korea University Anam Hospital, Seoul, Korea.
- 7Department of Urology, Dongguk University College of Medicine, Gyeongju, Korea.
- 8Department of Urology, Dankook University College of Medicine, Cheonan, Korea.
- 9Department of Urology, Inha University College of Medicine, Incheon, Korea.
- 10Department of Urology, Seoul National University Hospital, Seoul, Korea.
- 11Department of Urology, The Catholic University of Korea College of Medicine, Seoul, Korea. uroljy@catholic.ac.kr
- KMID: 2380835
- DOI: http://doi.org/10.5213/inj.2015.19.2.107
Abstract
- PURPOSE
In this study, we compared the treatment outcomes for an alpha-blocker between 2 groups of men, one with high sympathetic activity (HSA) and another with low sympathetic activity (LSA) or normal sympathetic activity.
METHODS
A total of 159 men (> or =50 years of age) with lower urinary tract symptoms resulting from benign prostatic hyperplasia were analyzed. We assigned patients to groups according to their sympathetic activity, which was evaluated by heart ratevariability measurements. HSA was defined as a low frequency/high frequency ratio greater than 1.6. All patients received 10mg of alfuzosin once a day for 12 weeks. The primary end point was a change in the total International Prostate SymptomScore (IPSS) at 12 weeks from baseline.
RESULTS
Sixty-seven men were assigned to the HSA group and 92 men were assigned to the LSA group. The baseline characteristics were not significantly different between the 2 groups, and the response to alfuzosin was good in both groups. Themean total IPSS change was not different between the groups. Both groups were not significantly different with respect to the changes in maximal flow rate, IPSS voiding or storage symptom subscores, quality of life, and rates of adverse drug events. TheHSA group showed a similar willingness to continue treatment compared to the LSA group, although their treatment satisfaction rating was lower.
CONCLUSIONS
The therapeutic effects of alfuzosin did not differ in regards to the differences in sympathetic activity, but treatment satisfaction ratings were lower in the HSA group.
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