J Korean Ophthalmol Soc.  2017 May;58(5):591-594. 10.3341/jkos.2017.58.5.591.

Eyelid Mass as Initial Presentation of Breast Cancer: A Case Report

• Lee Y
• Yang HJ
• Paik JS
• Yang SW

• KMID: 2378631
• DOI: http://doi.org/10.3341/jkos.2017.58.5.591

Abstract

PURPOSE
We report a case in which eyelid mass was the initial presentation of breast cancer. The diagnosis of breast cancer was made after lid biopsy.
CASE SUMMARY
A 41-year-old female patient presented with a painful mass on the left lower lid after 1 month. There was a pinkish mass in the lateral portion of the tarsal conjunctiva, and computed tomography revealed a mass with an irregular margin on the lower lid connected to the left lacrimal gland. Biopsy was performed at the tarsal conjunctiva of the left eye, and histopathologic examination was suggestive of malignant epithelial cell neoplasm, especially metastatic carcinoma in the breast. The patient was diagnosed as having invasive ductal cancer, for which she is currently receiving chemotherapy.
CONCLUSIONS
Metastases to the eyelid are very rare, accounting for less than 1% of all malignant eyelid lesions. We report a patient who presented with an eyelid mass as the initial presentation of breast cancer, which was diagnosed with metastatic breast cancer.

Keyword

Breast cancer; Eyelid mass; Metastatic cancer

MeSH Terms

Adult
Biopsy
Breast Neoplasms*
Breast*
Conjunctiva
Diagnosis
Drug Therapy
Epithelial Cells
Eyelids*
Female
Humans
Lacrimal Apparatus
Neoplasm Metastasis

Figure

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  Figure 1 Anterior segment photographs of the mass at initial presentation. (A) An irregular palpable mass (black arrow) is seen on the lateral side of the left lower eyelid. (B) Atypical upper and lower lid swelling is seen on left eye.

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  Figure 2 Non-enhance Orbit computed tomography, showing Ill-defined, soft tissue density lesion in left lower eyelid, connected to left lacrimal gland. (A) Coronal view. (B) Axial view.

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  Figure 3 Overview dissection of biopsy of eyelid mass. Epithelioid cell proliferation and positive staining of (A) GCDFP-15 and (B) GATA-3 was seen, suggestive of breast origin metastatic carcinoma (A: GDCFP-15, ×40) (B: GATA-3, ×10).

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