J Korean Med Sci.  2017 Jun;32(6):968-973. 10.3346/jkms.2017.32.6.968.

Effects of Adrenal Androgen Levels on Bone Age Advancement in Prepubertal Children: Using the Ewha Birth and Growth Cohort Study

Affiliations
  • 1Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
  • 2Department of Preventive Medicine, Ewha Womans University College of Medicine, Seoul, Korea.
  • 3Clinical Trial Center, Mokdong Hospital, Ewha Womans University, Seoul, Korea.
  • 4Department of Obstetrics and Gynecology, Ewha Womans University College of Medicine, Seoul, Korea.
  • 5Department of Anatomy, Ewha Womans University College of Medicine, Seoul, Korea.
  • 6Department of Pediatrics, Ewha Womans University College of Medicine, Seoul, Korea.
  • 7College of Pharmacy, Ewha Womans University, Seoul, Korea. hyesk@ewha.ac.kr

Abstract

Bone age (BA) advancement in prepubertal children may be associated with earlier onset of puberty and obesity. This study aimed to define the effects of adrenal androgen levels on the advancement of BA in prepubertal children, independent of obesity. During July and August 2011, we examined BA in 200 prepubertal children aged 7-9 years who were part of the Ewha Birth & Growth Cohort Study. BA was assessed by the Greulich-Pyle method. An index of BA advancement was calculated as the ratio of BA to chronological age (CA) (BA/CA), and this ratio was classified into 3 tertiles. We analyzed the relationship between BA advancement and anthropometric characteristics and adrenal hormone levels. The number of overweight children increased from the first group to the third group (P(Trend) = 0.03). The levels of adrenal androgens showed a significant positive correlation with the tertile groups after adjusting for age and sex (testosterone: r = 0.26, P < 0.001; dehydroepiandrosterone: r = 0.21, P < 0.001; androstenedione: r = 0.20, P < 0.001). Further, after controlling for body mass index (BMI), sex, and age, the BA/CA was found to be positively correlated with androstenedione (β = 0.04, R² = 3.7%) and testosterone levels (β = 0.05, R² = 4.7%). Based on our results, it is suggested that adrenal androgen levels are associated with BA advancement independent of BMI.

Keyword

Adrenal Cortex Hormone; Bone Age; Children; Obesity

MeSH Terms

Adolescent
Androgens
Androstenedione
Body Mass Index
Child*
Cohort Studies*
Dehydroepiandrosterone
Humans
Methods
Obesity
Overweight
Parturition*
Puberty
Testosterone
Androgens
Androstenedione
Dehydroepiandrosterone
Testosterone
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